| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CD130; GP130; CDW130; IL-6RB |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human IL6ST |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL6ST抗体的3篇参考文献的简要列举：
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1. **文献名称**: "Targeting the IL-6/JAK/STAT3 pathway in human malignancies"
**作者**: Johnson, D.E., et al.
**摘要**: 该综述讨论了IL-6信号通路(包括IL6ST/gp130)在癌症中的作用，并总结了靶向该通路的抗体及小分子抑制剂的研究进展，强调抗IL6ST抗体在抑制肿瘤生长和转移中的潜力。
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2. **文献名称**: "Structural basis of the gp130 cytokine receptor signaling revealed by cryo-EM"
**作者**: Xu, Y., et al.
**摘要**: 利用冷冻电镜解析了gp130(IL6ST)与IL-6/IL-6Rα复合物的高分辨率结构，通过特异性抗体验证了受体结合位点，为设计靶向IL6ST的抗肿瘤抗体提供了结构依据。
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3. **文献名称**: "Anti-gp130 antibody inhibits inflammation and bone erosion in collagen-induced arthritis models"
**作者**: Nowell, M.A., et al.
**摘要**: 研究证明抗gp130抗体通过阻断IL-6/IL6ST信号通路，显著减轻类风湿性关节炎模型中的炎症反应和骨侵蚀，提示其作为自身免疫疾病治疗策略的可行性。
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注：以上文献信息为示例，实际引用时需核对原文准确性及发表年份。如需具体文献，建议通过PubMed或Google Scholar以“IL6ST antibody”“gp130 therapeutic antibody”等关键词检索。
The IL6ST antibody targets the interleukin-6 signal transducer (IL6ST), also known as gp130. a key component of the receptor complex for IL-6 and related cytokines (e.g., IL-11. CNTF, LIF). As a shared signaling subunit, gp130 mediates downstream activation of JAK/STAT, MAPK, and PI3K pathways, influencing processes like inflammation, immune regulation, and cell survival. Dysregulation of gp130 is linked to chronic inflammatory diseases (e.g., rheumatoid arthritis), cancers, and autoimmune disorders, making it a therapeutic and diagnostic focus.
IL6ST antibodies are essential tools for studying gp130 expression, localization, and function in research. They enable detection of gp130 in assays like Western blotting, immunohistochemistry, and flow cytometry, aiding investigations into cytokine signaling mechanisms. Therapeutic antibodies targeting IL6ST or its associated pathways aim to modulate hyperactive signaling in diseases. For example, inhibitors blocking IL-6/gp130 interactions are explored for cancer and inflammatory conditions. However, challenges remain in balancing efficacy and safety due to gp130's broad physiological roles.
In summary, IL6ST antibodies serve as critical reagents for both basic research and drug development, offering insights into cytokine biology and pathways relevant to multiple diseases.
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