| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RCD4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CACNA2D4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CACNA2D4抗体的3篇假设性参考文献示例，供参考：
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1. **文献名称**：*"CACNA2D4 expression in neuroendocrine tumors: a novel biomarker explored via immunohistochemistry"*
**作者**：Smith A, Johnson R, et al.
**摘要**：本研究利用特异性CACNA2D4抗体，通过免疫组化技术检测其在神经内分泌肿瘤中的表达，发现CACNA2D4蛋白水平与肿瘤分化程度相关，提示其作为潜在诊断标志物的可能性。
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2. **文献名称**：*"Functional characterization of CACNA2D4 in retinal neurons using antibody-mediated protein localization"*
**作者**：Zhang Y, Lee H, et al.
**摘要**：通过Western blot和免疫荧光技术，使用CACNA2D4抗体揭示该蛋白在视网膜神经元中的亚细胞定位，证实其参与钙信号调控及光感受器功能维持。
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3. **文献名称**：*"CACNA2D4 antibody validation in knockout models: implications for epilepsy research"*
**作者**：Brown K, Müller S, et al.
**摘要**：本研究通过CACNA2D4基因敲除小鼠模型，验证了多克隆抗体在脑组织中的特异性，并发现CACNA2D4缺失导致异常神经元兴奋性，可能与癫痫发病机制相关。
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注：以上文献为示例，实际引用需以真实发表的文献为准。建议通过PubMed或Google Scholar以关键词“CACNA2D4 antibody”或“CACNA2D4 immunohistochemistry”检索最新研究。
The CACNA2D4 antibody targets the protein encoded by the CACNA2D4 gene, a member of the α2δ subunit family that regulates voltage-gated calcium channels (VGCCs). These channels mediate calcium influx into cells, critical for processes like neurotransmitter release, muscle contraction, and gene expression. The α2δ subunits enhance channel trafficking and stabilize pore-forming α1 subunits. CACNA2D4 is predominantly expressed in the retina and nervous system, suggesting a specialized role in visual signal transduction and neuronal excitability. Mutations in CACNA2D4 have been linked to retinal disorders, including cone-rod dystrophy and night blindness, highlighting its importance in photoreceptor function.
CACNA2D4 antibodies are essential tools for studying the protein's expression, localization, and interactions in both physiological and pathological contexts. Researchers use these antibodies in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore CACNA2D4's involvement in retinal degeneration, synaptic plasticity, and neurological diseases. Additionally, they aid in identifying potential therapeutic targets by elucidating mechanisms underlying calcium channel dysfunction. Despite its niche expression, CACNA2D4's association with sensory and neurological pathways underscores its broader relevance in biomedical research. Commercial antibodies vary in specificity, necessitating rigorous validation to ensure reliability in experimental models.
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