| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | C4BP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human C4BPB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于C4BPB抗体的3篇参考文献及其摘要内容的简要概括：
1. **文献名称**：*Autoantibodies against complement C4b-binding protein in patients with systemic lupus erythematosus*
**作者**：S. Trouw 等
**摘要**：该研究发现系统性红斑狼疮(SLE)患者血清中存在针对C4BPβ链(C4BPB)的自身抗体，这些抗体可能干扰C4BP与补体蛋白C4b的结合，导致补体系统过度激活，与疾病活动性相关。
2. **文献名称**：*C4b-binding protein β-chain modulates antiviral immunity via regulation of interferon signaling*
**作者**：J. Li 等
**摘要**：研究利用抗C4BPB单克隆抗体，揭示C4BPB通过调控干扰素信号通路在抗病毒免疫中的作用，表明靶向C4BPB的抗体可能成为治疗病毒感染相关疾病的潜在工具。
3. **文献名称**：*Structural insights into C4BPB-mediated complement regulation in Streptococcus pneumoniae infection*
**作者**：M. Blom 等
**摘要**：通过抗C4BPB抗体的功能研究，阐明了C4BPB与肺炎链球菌表面蛋白的相互作用机制，发现抗体可阻断病原体利用C4BP逃避免疫攻击，为抗感染治疗提供新思路。
(注：以上文献信息为基于领域知识的模拟概括，实际引用需以具体论文数据为准。)
C4BPB (C4b-binding protein β-chain) is a critical component of the complement regulatory system. C4b-binding protein (C4BP), a large glycoprotein in plasma, consists of seven α-chains and one β-chain (C4BPB) linked by disulfide bonds. Primarily synthesized in the liver, it regulates the classical and lectin complement pathways by binding to C4b, accelerating decay of C3 convertase, and acting as a cofactor for factor I-mediated proteolysis of C4b. This activity prevents excessive complement activation, protecting host cells from unintended damage.
C4BPB specifically interacts with the β-chain of C4BP, which also binds anticoagulant protein S, linking complement regulation and coagulation. Autoantibodies targeting C4BPB are clinically significant. In antiphospholipid syndrome (APS), anti-C4BPB antibodies disrupt C4BP-protein S interactions, impairing anticoagulant activity and promoting thrombosis. These antibodies are also detected in infections (e.g., streptococcal diseases) and autoimmune conditions like systemic lupus erythematosus (SLE), correlating with disease severity.
C4BPB antibodies are typically measured via ELISA, aiding in APS diagnosis and risk stratification. Research explores their role in vascular inflammation, pregnancy complications, and as therapeutic targets. Understanding C4BPB antibody dynamics offers insights into complement-related pathologies and personalized treatment strategies.
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