Rabbit Polyclonal ULK4 Antibody

The ULK4 (Unc-51-like kinase 4) antibody is a research tool designed to detect and study the ULK4 protein, a member of the serine/threonine kinase family implicated in critical cellular processes. ULK4 shares structural homology with other Unc-51 kinases, featuring an N-terminal kinase domain and a C-terminal region involved in protein interactions. While its exact biological functions remain under investigation, ULK4 is hypothesized to regulate signaling pathways linked to neurodevelopment, ciliogenesis, and cell cycle control. Studies associate ULK4 mutations with neurodevelopmental disorders, hydrocephalus, and psychiatric conditions, highlighting its potential role in brain development and disease. ULK4 antibodies are widely utilized in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and post-translational modifications. Researchers employ these antibodies to explore ULK4's involvement in diseases such as cancer, where aberrant expression may influence tumor progression, or in neurological models, where ULK4-deficient mice exhibit structural brain defects. Validated antibodies are essential for distinguishing ULK4 isoforms and ensuring specificity in diverse experimental systems. Ongoing research aims to clarify ULK4's kinase targets, regulatory mechanisms, and therapeutic potential, positioning ULK4 antibodies as key reagents in both basic and translational studies.