| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UBC7 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UBE2G2抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*UBE2G2 regulates Wnt/β-catenin signaling and promotes hepatocellular carcinoma progression*
**作者**：Li, X. et al.
**摘要**：该研究利用UBE2G2抗体通过免疫印迹和免疫组化分析，发现UBE2G2在肝癌组织中高表达，并通过增强Wnt/β-catenin信号通路促进肿瘤侵袭和转移。
2. **文献名称**：*UBE2G2-mediated ubiquitination drives proteasomal degradation of tumor suppressor PTEN*
**作者**：Wang, Y. et al.
**摘要**：研究通过UBE2G2抗体进行免疫共沉淀实验，揭示UBE2G2与PTEN相互作用并介导其泛素化降解，导致PI3K/AKT通路异常激活，促进肿瘤发生。
3. **文献名称**：*Antibody-based profiling of UBE2G2 expression in glioblastoma reveals prognostic significance*
**作者**：Chen, H. et al.
**摘要**：利用UBE2G2特异性抗体对胶质母细胞瘤样本进行组织芯片分析，发现其高表达与患者生存期缩短显著相关，提示其作为潜在预后标志物的价值。
注：以上文献信息为示例性质，实际引用时需核实具体来源及内容。
The UBE2G2 antibody is a tool used to detect and study the ubiquitin-conjugating enzyme E2 G2 (UBE2G2), a key component of the ubiquitin-proteasome system (UPS). UBE2G2. part of the E2 enzyme family, facilitates the transfer of ubiquitin to substrate proteins in conjunction with E3 ligases, marking them for proteasomal degradation or functional modulation. This enzyme is involved in endoplasmic reticulum-associated degradation (ERAD), helping to eliminate misfolded proteins by tagging them with K48-linked polyubiquitin chains. Dysregulation of UBE2G2 has been linked to diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, where protein homeostasis is disrupted.
UBE2G2 antibodies are widely used in research to investigate protein ubiquitination dynamics, enzyme-substrate interactions, and UPS-related pathways. They enable detection of UBE2G2 expression levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies also aid in studying UBE2G2’s role in cellular stress responses, apoptosis, and cancer progression, where its overexpression or inhibition may influence tumor growth or drug resistance. Additionally, they are critical in validating CRISPR/Cas9 knockout models or siRNA-mediated silencing in functional studies. High specificity and validation for cross-reactivity are essential for reliable data, making UBE2G2 antibodies vital for advancing understanding of ubiquitination mechanisms and therapeutic targeting.
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