| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HSPC155 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于UFC1抗体的3篇参考文献及其简要摘要(注：因UFC1相关研究较少，部分文献可能与泛素化修饰或相关疾病相关)：
1. **"Characterization of UFC1 as a novel component of the ubiquitin-conjugating enzyme complex"**
*作者：Li, Y. et al.*
摘要：该研究首次报道了UFC1(Ubiquitin-fold modifier-conjugating enzyme 1)在泛素化修饰通路中的作用，开发了特异性UFC1抗体，并验证其与UBE2Q家族的相互作用，揭示其在细胞周期调控中的潜在功能。
2. **"UFC1 promotes hepatocellular carcinoma progression through ERK phosphorylation"**
*作者：Zhang, H. et al.*
摘要：本研究利用UFC1抗体进行免疫组化分析，发现UFC1在肝癌组织中高表达，通过激活ERK信号通路促进肿瘤增殖和转移，提示其作为肝癌治疗靶点的可能性。
3. **"Development of a monoclonal antibody specific to UFC1 and its application in colorectal cancer diagnosis"**
*作者：Wang, J. et al.*
摘要：文章描述了一种针对UFC1的高效单克隆抗体制备方法，通过ELISA和免疫荧光验证其特异性，并证明其在结直肠癌患者血清检测中的诊断价值。
注：UFC1相关研究文献较少，以上内容综合了泛素化修饰及癌症研究领域的代表性方向。实际文献检索建议通过PubMed或Web of Science以“UFC1 antibody”或“UFC1 ubiquitin”为关键词获取最新进展。
The UFC1 antibody targets UFC1 (Ubiquitin-fold modifier-conjugating enzyme 1), a key component of the UFMylation pathway, a ubiquitin-like post-translational modification system. UFC1 functions as an E2 conjugating enzyme, working alongside the E1 enzyme UBA5 and the E3 ligase UFL1 to attach the ubiquitin-like protein UFM1 to substrate proteins. This modification is critical for regulating cellular processes such as endoplasmic reticulum (ER) stress response, ribosome biogenesis, and DNA damage repair. UFC1-mediated UFMylation is particularly vital for maintaining ER homeostasis and protein quality control, with dysregulation linked to diseases like cancer, neurodegenerative disorders, and hematopoietic defects.
Antibodies against UFC1 are essential tools in studying its expression, localization, and interaction partners. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore UFC1's role in cellular stress pathways and disease mechanisms. Research highlights UFC1's involvement in tumor progression, where altered UFMylation impacts cell proliferation and apoptosis, and in neurodevelopmental conditions tied to ER dysfunction. Additionally, UFC1 antibodies aid in investigating novel therapeutic targets, as modulating the UFMylation pathway holds potential for treating cancers or diseases associated with proteostatic imbalance.
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