| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NA88A; HPX42B; VENTX2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于VENTX抗体的虚构示例文献(仅供格式参考，建议通过PubMed或Google Scholar检索真实文献)：
1. **文献名称**: *VENTX regulates hematopoietic stem cell differentiation through Notch signaling*
**作者**: Smith A, et al.
**摘要**: 研究报道VENTX蛋白在造血干细胞分化中的调控作用，通过Notch通路影响细胞命运。使用VENTX抗体进行免疫荧光和Western blot，证实其在早期造血祖细胞中的高表达。
2. **文献名称**: *VENTX expression in acute myeloid leukemia: Prognostic implications*
**作者**: Lee JH, et al.
**摘要**: 分析VENTX在AML患者中的表达水平，发现其高表达与不良预后相关。采用VENTX抗体进行免疫组化，揭示其作为潜在生物标志物的临床价值。
3. **文献名称**: *VENTX antibody validation for functional studies in cellular reprogramming*
**作者**: Garcia R, et al.
**摘要**: 验证VENTX抗体的特异性，证实其适用于ChIP-seq和流式细胞术，研究VENTX在体细胞重编程中对多能性基因的抑制作用。
4. **文献名称**: *Structural insights into VENTX-DNA interaction using epitope-specific antibodies*
**作者**: Chen X, et al.
**摘要**: 通过表位特异性VENTX抗体解析其与DNA结合域的结构，阐明其在转录调控中的分子机制，为靶向治疗提供依据。
(注：以上为模拟示例，实际文献需通过学术数据库查询。)
VENTX (also known as VENTX2 or HPNX) is a member of the SINE homeobox transcription factor family, which plays critical roles in embryonic development, particularly in mesoderm patterning and hematopoiesis. Initially identified as a human homolog of the Xenopus Xvent gene, VENTX is implicated in regulating cell fate decisions, differentiation, and proliferation. In hematopoietic stem cells (HSCs), VENTX is thought to suppress differentiation, maintaining stem cell self-renewal by interacting with key regulators like GATA2 and PU.1. Its expression is tightly controlled during development and is often silenced in mature tissues, but aberrant reactivation has been linked to cancers, including leukemia and solid tumors. Studies suggest VENTX overexpression may promote oncogenesis by inhibiting apoptosis and enhancing cell cycle progression.
VENTX antibodies are essential tools for detecting and studying the protein's expression, localization, and function in both normal and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to explore VENTX's role in stem cell biology, cancer mechanisms, and potential therapeutic targeting. Reliable VENTX antibodies help validate its interactions with signaling pathways (e.g., Wnt/β-catenin) and its impact on transcriptional networks. As research advances, these antibodies remain crucial for deciphering VENTX's dual roles in development and disease, offering insights for diagnostic or therapeutic applications.
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