| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FOAP-4; GPI-80 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human VNN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于VNN2抗体的3篇参考文献及其简要摘要：
1. **标题**: *Vanin-2 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity*
**作者**: Berthier, C.C., et al.
**摘要**: 研究利用VNN2抗体检测肠道上皮细胞中VNN2的表达，发现其通过调节PPARγ活性促进炎症因子释放，参与结肠炎发病机制。
2. **标题**: *VNN2 overexpression is associated with poor prognosis in colorectal cancer and promotes tumor progression*
**作者**: Martin, F., et al.
**摘要**: 通过免疫组化(VNN2抗体标记)发现结直肠癌中VNN2高表达与预后不良相关，体外实验表明其通过促进细胞迁移/侵袭加速肿瘤进展。
3. **标题**: *Vanin-2 regulates systemic glutathione metabolism and modulates insulin resistance in mice*
**作者**: Okumura, A., et al.
**摘要**: 研究利用VNN2抗体分析小鼠代谢组织(肝脏、脂肪)中VNN2的表达，揭示其通过调控谷胱甘肽代谢影响胰岛素敏感性，提示与肥胖相关代谢紊乱的关联。
若需扩展，可补充关于VNN2酶活性或结构研究的文献。
VNN2 (Vanin-2) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein belonging to the vanin family, which includes VNN1 and VNN3. It is encoded by the *VNN2* gene and is highly expressed in tissues such as the intestine, liver, and kidney. Functionally, VNN2 exhibits pantetheinase activity, catalyzing the hydrolysis of pantetheine to produce cysteamine and pantothenic acid (vitamin B5). This enzymatic role links VNN2 to cellular metabolism, oxidative stress responses, and inflammation.
VNN2 is implicated in innate immunity, particularly in regulating leukocyte migration and adhesion during inflammatory processes. It interacts with integrins and modulates extracellular matrix remodeling, influencing tissue repair and inflammatory diseases. Research highlights its association with pathologies like inflammatory bowel disease (IBD), atherosclerosis, and cancer. In cancer, VNN2 overexpression has been observed in certain malignancies, potentially contributing to tumor progression and metastasis via pathways involving oxidative signaling and immune evasion.
Antibodies targeting VNN2 are critical tools for studying its expression, localization, and function. They enable applications such as immunohistochemistry, flow cytometry, and Western blotting, aiding in the exploration of VNN2's role in disease mechanisms and its potential as a therapeutic target or biomarker. Recent studies also investigate its utility in modulating metabolic-inflammatory crosstalk, emphasizing its dual role in health and disease.
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