Rabbit Polyclonal ALKBH8 Antibody

The ALKBH8 antibody is a crucial tool for studying the AlkB homolog 8 protein, a member of the AlkB family of dioxygenases involved in RNA and DNA repair. ALKBH8 specifically catalyzes the post-transcriptional modification of transfer RNA (tRNA) by mediating the methylation of specific nucleotides, such as wybutosine, which stabilizes codon-anticodon interactions during translation. This enzyme plays a role in maintaining translational fidelity and cellular stress responses. The ALKBH8 antibody is widely used in research to detect and quantify ALKBH8 expression in various biological samples via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It helps investigate ALKBH8's involvement in diseases, including cancer, where dysregulation of tRNA modifications may promote tumor progression. Additionally, the antibody aids in exploring ALKBH8's interaction with other proteins or nucleic acids through co-immunoprecipitation assays. Validated for specificity in multiple species (e.g., human, mouse), it is essential for functional studies, such as assessing ALKBH8 knockdown or overexpression effects on cellular processes. Research using this antibody has also linked ALKBH8 to neurological disorders and metabolic pathways, highlighting its broader biological significance. Overall, the ALKBH8 antibody is pivotal for advancing understanding of epitranscriptomic regulation and its implications in health and disease.