| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | UG0636c06 |
| WB Predicted band size | 64 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CAPS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CAPS2(CADPS2)抗体应用相关的模拟参考文献，基于学术研究背景合理构建：
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1. **文献名称**: *CADPS2 regulates exocytosis and interacts with autism-spectrum disorder risk genes*
**作者**: Sadakata T, Furuichi T
**摘要**: 本研究通过Western blot和免疫组化技术，利用特异性CAPS2抗体揭示CADPS2蛋白在小鼠脑组织突触小泡分泌中的关键作用。抗体验证显示其在海马和皮层中高表达，并发现CADPS2与SHANK3等自闭症相关蛋白存在相互作用，提示其在神经发育障碍中的潜在机制。
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2. **文献名称**: *Developmental expression of CADPS2 in human and mouse brains*
**作者**: Nakamura K, Takumi T
**摘要**: 通过CAPS2抗体的免疫荧光分析，研究比较了人类和小鼠胚胎及成年脑组织中CADPS2的时空表达模式。结果显示其在神经元迁移和轴突导向阶段显著上调，提示CADPS2参与早期神经环路形成，为解释其与自闭症易感性的关联提供组织学证据。
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3. **文献名称**: *Altered CAPS2 expression in schizophrenia: A postmortem study*
**作者**: Sawada K, Hashimoto R
**摘要**: 使用CAPS2抗体对精神分裂症患者尸检前额叶皮层进行定量分析，发现CADPS2蛋白水平显著降低。进一步RNA干扰实验表明，其表达下调导致谷氨酸释放异常，提示CADPS2可能通过调节神经递质分泌参与精神疾病病理过程。
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**注**：以上文献为示例性质，实际研究需通过PubMed等数据库检索真实论文(可尝试关键词：CADPS2 antibody、CAPS2 neurological function)。若需具体文献，建议补充更详细的研究背景或抗体货号等信息。
CAPS2 (Calcium-dependent activator protein for secretion 2), also known as CADPS2. is a member of the CAPS/CADPS protein family, which regulates dense-core vesicle exocytosis and neurotransmitter release. Initially identified in the 1990s, CAPS2 is primarily expressed in the brain, particularly in regions like the cerebellum, hippocampus, and cerebral cortex, where it plays a critical role in synaptic vesicle maturation, neuropeptide secretion, and synaptic plasticity. Structurally, it contains conserved domains such as a pleckstrin homology (PH) domain and a C2 domain, enabling calcium-dependent interactions with membranes and signaling molecules.
Research highlights its involvement in neurodevelopmental processes, including neuronal differentiation and circuit formation. CAPS2 has been linked to neuropsychiatric disorders; genetic variations or deletions in the CAPS2/CADPS2 gene are associated with autism spectrum disorder (ASD), schizophrenia, and intellectual disabilities. Studies in knockout mice reveal deficits in social behavior and synaptic transmission, supporting its functional relevance in brain development.
CAPS2 antibodies are widely used to investigate its expression patterns, subcellular localization, and molecular interactions in neurological research. These antibodies aid in elucidating its role in vesicle trafficking pathways and disease mechanisms, making them essential tools for understanding both normal neural function and pathological conditions.
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