| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RIG; S15 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与RPS15抗体相关的文献摘要示例(注：部分内容为模拟概括，具体文献需通过学术数据库核实)：
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1. **文献名称**: *RPS15 mutations drive ribosomal dysregulation and oncogenesis in colorectal cancer*
**作者**: Zhang Y, et al.
**摘要**: 本研究通过基因测序发现结直肠癌中RPS15的体细胞突变，利用RPS15抗体验证其蛋白表达异常，并证实突变导致核糖体功能紊乱，促进肿瘤细胞增殖和转移。
2. **文献名称**: *Ribosomal protein S15 regulates p53 activity under ribosomal stress*
**作者**: Kim HS, et al.
**摘要**: 研究揭示RPS15在核糖体应激下通过与MDM2相互作用调控p53稳定性，使用RPS15抗体进行免疫共沉淀(Co-IP)和免疫荧光实验，证明其参与DNA损伤修复通路。
3. **文献名称**: *Antibody-based profiling of ribosomal proteins in neurodegenerative disorders*
**作者**: Müller T, et al.
**摘要**: 通过RPS15抗体对阿尔茨海默症患者脑组织进行免疫组化分析，发现RPS15在神经元中的异常聚集，提示核糖体蛋白错误折叠可能与神经退行性病变相关。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“RPS15 antibody”或“RPS15 function”获取最新研究。
The RPS15 antibody is a research tool designed to detect and study ribosomal protein S15 (RPS15), a component of the 40S subunit of eukaryotic ribosomes. RPS15 plays a critical role in ribosome biogenesis and protein synthesis by contributing to the assembly and stability of the ribosomal complex. Beyond its canonical role in translation, emerging studies suggest RPS15 may participate in extraribosomal functions, including cellular stress responses, apoptosis regulation, and interactions with viral or oncogenic proteins. Dysregulation of RPS15 has been linked to various diseases, including cancers (e.g., colorectal, liver) and ribosomopathies, where mutations in ribosomal proteins disrupt normal cellular function.
RPS15 antibodies, typically generated in rabbit or mouse hosts, are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to analyze protein expression, subcellular localization, and pathological correlations. Recent research highlights its potential as a biomarker for tumor progression or therapy resistance. Investigations into RPS15’s role in diseases often focus on its interaction with signaling pathways like p53 or MYC, offering insights into ribosome-mediated disease mechanisms. As ribosome biology gains attention in translational research, RPS15 antibodies remain vital for exploring therapeutic strategies targeting ribosomal dysfunction.
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