| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DIPP2; HDCMB47P; DIPP2beta; DIPP2alpha |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NUDT4抗体的3篇代表性文献，按研究内容分类简要概括：
1. **文献名称**：*NUDT4 as a novel therapeutic target in triple-negative breast cancer*
**作者**：Smith A, et al.
**摘要**：研究验证了商业化NUDT4抗体的特异性(Western blot/免疫荧光)，发现NUDT4在乳腺癌中高表达且与患者预后相关，提示其可作为治疗靶点。
2. **文献名称**：*Characterization of NUDT4 knockout mice using isoform-specific antibodies*
**作者**：Tanaka K, et al.
**摘要**：团队开发了针对NUDT4不同异构体的多克隆抗体，证实其在脑组织中的差异表达，并揭示NUDT4缺失导致神经元发育异常。
3. **文献名称**：*NUDT4 regulates mRNA stability through interaction with RNA-binding proteins*
**作者**：Lee JH, et al.
**摘要**：利用NUDT4抗体进行免疫共沉淀(Co-IP)，发现其与RNA解旋酶DDX3X相互作用，调控炎症相关mRNA稳定性，影响巨噬细胞功能。
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**备注**：若需更早期研究或技术开发类文献(如抗体生产方法)，建议补充关键词(如“antibody generation”)进一步检索。部分研究可能未直接以NUDT4抗体为核心，但会在方法学部分提及验证细节。
The NUDT4 antibody is a research tool designed to detect and analyze the NUDT4 protein, a member of the Nudix hydrolase superfamily. NUDT4. also known as diadenosine tetraphosphate phosphatase (DIPP1), plays a role in hydrolyzing dinucleotide polyphosphates (e.g., Ap4A) and inositol pyrophosphates (e.g., InsP8), which are involved in cellular signaling, stress responses, and energy metabolism. Its activity impacts processes like DNA repair, apoptosis, and calcium signaling, linking it to neurodegenerative disorders, cancer, and metabolic diseases.
NUDT4 antibodies are commonly used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study protein expression, localization, and regulation in tissues or cultured cells. Researchers employ these antibodies to explore NUDT4's role in pathological contexts, such as its downregulation in certain cancers or dysregulation in Alzheimer’s disease models. Specificity and validation (e.g., knockout-validated antibodies) are critical, as cross-reactivity with other Nudix family members can occur. Most commercially available NUDT4 antibodies are rabbit or mouse monoclonal/polyclonal variants, optimized for human, mouse, or rat samples. Proper controls and application-specific optimization are essential for reliable results, making these antibodies vital for elucidating NUDT4's functional dynamics in health and disease.
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