| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | SSBP; mtSSB; Mt-SSB; SOSS-B1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SSBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SSBP1抗体的3篇示例参考文献(虚拟构建，仅供参考)：
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1. **文献名称**：*SSBP1 mutations impair mitochondrial DNA replication and cause autosomal dominant optic atrophy*
**作者**：Tiranti, V. et al.
**摘要**：本研究揭示了SSBP1基因突变导致线粒体DNA复制缺陷，引发常染色体显性视神经萎缩(ADOA)。通过使用特异性SSBP1抗体进行免疫印迹和免疫荧光实验，发现突变蛋白稳定性降低，并影响其在线粒体中的定位。
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2. **文献名称**：*Autoantibodies against SSBP1 in systemic lupus erythematosus: a novel biomarker for disease activity*
**作者**：Zhang, L. et al.
**摘要**：该研究首次报道了系统性红斑狼疮(SLE)患者血清中存在抗SSBP1自身抗体。通过ELISA和蛋白质印迹验证，发现抗SSBP1抗体水平与疾病活动度呈正相关，提示其可能作为SLE的新型生物标志物。
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3. **文献名称**：*Development and validation of a monoclonal antibody specific for human SSBP1 in chromatin immunoprecipitation assays*
**作者**：Wang, Y. et al.
**摘要**：文章描述了一种高特异性抗人SSBP1单克隆抗体的开发与验证。该抗体成功应用于染色质免疫沉淀(ChIP)和免疫共沉淀(Co-IP)实验，为研究SSBP1在DNA修复和线粒体功能中的机制提供了可靠工具。
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注：以上文献为示例性内容，实际研究中请通过PubMed、Google Scholar等平台检索真实发表的论文。
SSBP1 (Single-Stranded DNA Binding Protein 1) is a critical protein involved in maintaining mitochondrial genome stability by binding to single-stranded DNA (ssDNA) during replication and repair. It functions as a tetramer, interacting with other mitochondrial enzymes like DNA polymerase γ and helicase TWINKLE to facilitate proper mtDNA synthesis. SSBP1 mutations are linked to human diseases, including autosomal dominant optic atrophy (ADOA) and early-onset mitochondrial disorders, highlighting its essential role in mitochondrial function.
Antibodies targeting SSBP1 are vital tools in studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate SSBP1's involvement in mitochondrial DNA maintenance, cellular stress responses, and disease mechanisms. Commercial SSBP1 antibodies are typically raised in hosts such as rabbits or mice, with validation in knockdown models or SSBP1-deficient cells to ensure specificity. Researchers rely on these antibodies to explore SSBP1's regulatory roles in metabolic pathways, aging, and pathologies like cancer or neurodegenerative diseases, where mitochondrial dysfunction is implicated. Reliable SSBP1 detection aids in advancing understanding of mitochondrial biology and therapeutic targeting.
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