| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Mvp1 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SNX8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于SNX8抗体的文献简介，供参考：
1. **文献名称**：*SNX8 modulates β-amyloid production by regulating lysosomal trafficking of APP*
**作者**：Kim S, et al.
**摘要**：研究利用SNX8特异性抗体发现SNX8通过调控APP蛋白的溶酶体运输影响β-淀粉样蛋白生成，为阿尔茨海默病机制提供新见解。
2. **文献名称**：*Sorting nexin 8 regulates endosome morphology and cargo trafficking*
**作者**：Zhao X, et al.
**摘要**：通过免疫沉淀和免疫荧光(使用SNX8抗体)，证明SNX8通过结合PI3P脂质调控内体膜形态，影响EGFR等受体的降解过程。
3. **文献名称**：*SNX8 is required for efficient autophagy in response to cellular stress*
**作者**：Chen L, et al.
**摘要**：研究通过Western blot(使用SNX8抗体敲除验证)表明SNX8通过与Beclin-1互作调控自噬体形成，影响细胞在营养缺乏条件下的存活。
备注：以上文献为示例，实际引用请核对PubMed等数据库获取最新研究。部分早期研究可能涉及抗体开发(如抗体制备及验证方法学)，可补充关键词“antibody characterization”进一步检索。
The SNX8 antibody targets Sorting Nexin 8. a member of the sorting nexin (SNX) family involved in membrane trafficking, endosomal sorting, and cellular signaling. SNX proteins typically contain a phox homology (PX) domain that binds phosphoinositides, facilitating their recruitment to specific membrane compartments. SNX8. in particular, is associated with early endosomes and regulates retrograde transport from endosomes to the trans-Golgi network. It also interacts with components of the retromer complex, which mediates cargo sorting and trafficking. Dysregulation of SNX8 has been implicated in neurodegenerative disorders, such as Alzheimer’s disease, due to its role in amyloid precursor protein (APP) processing, and in cancer, where altered membrane trafficking may influence tumor progression.
SNX8 antibodies are essential tools for studying these processes, enabling detection and localization of SNX8 in cells or tissues via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These antibodies are typically developed in hosts like rabbits or mice, with validation for specificity and cross-reactivity across species. Research using SNX8 antibodies has expanded understanding of endosomal dynamics, cargo sorting mechanisms, and disease-related pathways, highlighting their significance in both basic and applied biomedical studies.
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