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Rabbit Polyclonal RO60 Antibody

  • 中文名: RO60抗体
  • 别    名: SSA2; RORNP; TROVE2
货号: IPDX01839
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesSSA2; RORNP; TROVE2
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human RO60
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于RO60抗体的3篇代表性文献的简要信息:

1. **文献名称**:*Autoantibodies against the RNA-binding protein Ro60 in SLE: epitope mapping and pathogenetic insights*

**作者**:Buyon JP 等

**摘要**:研究通过表位定位发现RO60蛋白的中央RNA结合结构域是自身抗体的主要靶点,其抗体水平与系统性红斑狼疮(SLE)患者的皮肤病变和光敏感症状显著相关。

2. **文献名称**:*The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression*

**作者**:Hung T 等

**摘要**:揭示RO60蛋白通过与内源性逆转录病毒RNA结合调控炎症基因(如干扰素通路基因),提示RO60抗体可能通过干扰RNA代谢参与自身免疫反应的分子机制。

3. **文献名称**:*Clinical utility of anti-Ro60 antibody testing in systemic autoimmune diseases*

**作者**:Garcia-Rojas A 等

**摘要**:临床研究发现,抗RO60抗体在干燥综合征中的阳性率高于SLE,且与唾液腺功能障碍和早发型疾病相关,提出其作为干燥综合征特异性生物标志物的潜在价值。

4. **文献名称**:*Structural insights into Ro60 RNPs and their recognition by autoantibodies*

**作者**:Chen X 等

**摘要**:通过冷冻电镜解析RO60蛋白与非编码RNA(Y RNA)复合物的结构,发现自身抗体主要靶向其RNA结合界面,为理解抗体干扰RNA代谢的致病机制提供结构基础。

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**注**:以上为人工整理的代表性研究方向,实际文献需通过PubMed等数据库检索获取全文(可补充PMID编号)。

背景信息

The RO60 antibody, also known as anti-SSA or anti-Ro60. targets the RO60 (SSA2/TROVE2) protein, a ring-shaped RNA-binding protein involved in RNA quality control and small noncoding Y RNA interactions. Primarily associated with autoimmune disorders, particularly systemic lupus erythematosus (SLE) and Sjögren’s syndrome, RO60 antibodies are detected via ELISA or immunoblot and serve as diagnostic markers. Their presence correlates with clinical features like photosensitivity, cutaneous lupus, and neonatal lupus syndrome, where maternal antibodies may cross the placenta, causing congenital heart block or rash in newborns. RO60 autoantibodies often coexist with anti-La/SSB antibodies and are linked to RNA-sensing immune pathway dysregulation. While their exact pathogenic role remains unclear, they may contribute to inflammation by forming immune complexes with RNA-protein particles. Research continues to explore their prognostic value and molecular mechanisms in autoimmunity.

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