| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PI11; SCCA1; SCCA2; LEUPIN; SCCA-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human SERPINB4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SERPINB4抗体的3篇参考文献示例(内容为模拟概括，仅供参考)：
1. **文献名称**：*SERPINB4 as a prognostic biomarker in cutaneous squamous cell carcinoma*
**作者**：Scott LM, et al. (2019)
**摘要**：研究通过免疫组化(使用SERPINB4特异性抗体)发现，SERPINB4在皮肤鳞癌组织中高表达，并与患者不良预后相关，提示其可能作为潜在治疗靶点。
2. **文献名称**：*Role of SERPINB4 in modulating allergic inflammation*
**作者**：Tanaka H, et al. (2020)
**摘要**：利用抗SERPINB4抗体进行功能阻断实验，发现SERPINB4通过抑制蛋白酶活性加剧Th2型炎症反应，与过敏性皮炎发病机制相关。
3. **文献名称**：*SERPINB4 antibody-based detection in psoriatic skin lesions*
**作者**：Johnson R, et al. (2018)
**摘要**：通过Western blot和免疫荧光(使用SERPINB4抗体)证实银屑病皮损中SERPINB4表达显著上调，可能与表皮屏障功能障碍有关。
4. **文献名称**：*SERPINB4 promotes tumor immune evasion via antibody-mediated pathway analysis*
**作者**：Lee S, et al. (2021)
**摘要**：研究采用抗SERPINB4抗体揭示其在肿瘤微环境中抑制T细胞活性，提示靶向SERPINB4可能增强免疫治疗响应。
(注：以上文献信息为示例，实际引用请以真实数据库检索结果为准。)
SERPINB4. a member of the serine protease inhibitor (serpin) superfamily, is encoded by the SERPINB4 gene located on chromosome 18q21.3. It is also known as squamous cell carcinoma antigen 2 (SCCA2) and shares structural homology with SERPINB3 (SCCA1), both clustered in the same genomic region. Primarily expressed in squamous epithelial cells, SERPINB4 inhibits proteases like kallikreins and cathepsins, playing roles in immune regulation, inflammation, and tissue remodeling. Dysregulation of SERPINB4 is linked to squamous cell carcinomas (e.g., cervical, lung, head/neck cancers), where its overexpression correlates with tumor progression, metastasis, and apoptosis resistance. It is also implicated in inflammatory skin disorders such as psoriasis and atopic dermatitis, contributing to abnormal keratinocyte differentiation and immune activation.
SERPINB4 antibodies are critical tools for detecting this protein in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study SERPINB4 expression patterns in tissues or biofluids. These antibodies aid in exploring its role as a biomarker for cancer prognosis or therapeutic targeting. However, challenges include potential cross-reactivity with SERPINB3 due to high sequence similarity, necessitating rigorous validation. Ongoing research focuses on clarifying SERPINB4’s dual roles in tumorigenesis and inflammation, as well as its potential as a diagnostic or immunotherapeutic target in precision medicine.
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