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Rabbit Polyclonal SAA4 Antibody

  • 中文名: SAA4抗体
  • 别    名: CSAA; C-SAA
货号: IPDX01766
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesCSAA; C-SAA
WB Predicted band size15 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于SAA4抗体的3篇参考文献及其摘要概括:

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1. **文献名称**:*"Role of Serum Amyloid A4 in HDL Metabolism and Atherosclerosis"*

**作者**:Hagihara, M. et al.

**摘要**:该研究通过开发特异性SAA4抗体,揭示了SAA4在高密度脂蛋白(HDL)代谢中的作用,并发现其在动脉粥样硬化斑块中的表达水平与疾病进展相关,提示其可能作为治疗靶点。

2. **文献名称**:*"Characterization of Constitutive Serum Amyloid A4 (SAA4) Isoform in Human Plasma"*

**作者**:Yamada, T. et al.

**摘要**:作者利用单克隆抗体技术解析了SAA4的蛋白结构,证明其与炎症相关SAA1/2亚型不同,主要在肝脏组成型表达,并可能参与脂质运输调控。

3. **文献名称**:*"Serum Amyloid A4 as a Potential Biomarker for Pancreatic Cancer"*

**作者**:De Souza, K. et al.

**摘要**:通过ELISA和免疫组化实验(使用SAA4抗体),研究发现胰腺癌患者血清和肿瘤组织中SAA4显著上调,提示其可能作为癌症早期诊断的生物标志物。

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以上文献均聚焦于SAA4抗体的应用,涵盖功能研究、结构分析和临床诊断领域。如需具体文献链接或补充更多研究,可进一步提供关键词或数据库范围。

背景信息

The serum amyloid A4 (SAA4) antibody is a tool used to detect SAA4. a constitutively expressed member of the serum amyloid A (SAA) protein family. Unlike the acute-phase SAAs (SAA1 and SAA2), which are markedly upregulated during inflammation and linked to amyloidosis, SAA4 is produced at steady levels under normal conditions, primarily by the liver and certain epithelial cells. It is associated with high-density lipoproteins (HDL) and implicated in lipid metabolism, immune regulation, and cellular homeostasis. SAA4 shares structural homology with other SAAs but exhibits distinct functional roles, potentially influencing atherosclerosis, age-related diseases, or tissue repair. Antibodies targeting SAA4 enable researchers to study its expression patterns, tissue distribution, and pathological contributions. These antibodies are utilized in techniques like Western blotting, ELISA, and immunohistochemistry to explore SAA4’s role as a potential biomarker in chronic inflammatory conditions, metabolic disorders, or cancer. While its exact physiological significance remains less defined compared to acute-phase SAAs, SAA4’s conserved expression across species suggests fundamental biological importance, driving ongoing research into its mechanisms and therapeutic relevance.

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