| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 120 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SENP7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与SENP7抗体相关的参考文献示例(文献信息为模拟生成，仅供参考)：
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1. **文献名称**: *SENP7 regulates chromatin reorganization through deSUMOylation of HP1γ*
**作者**: Bawa-Khalfe T, et al.
**摘要**: 研究报道SENP7通过特异性去SUMO化HP1γ蛋白调控异染色质稳定性。实验中利用SENP7抗体进行免疫共沉淀(Co-IP)和Western blot验证其与HP1γ的相互作用，并发现SENP7缺失导致基因组不稳定。
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2. **文献名称**: *SENP7-mediated poly-SUMO chain editing in DNA damage response*
**作者**: Matic I, et al.
**摘要**: 揭示SENP7通过剪切多聚SUMO链参与DNA损伤修复通路。研究使用SENP7抗体进行免疫荧光定位，显示其在细胞核内富集于DNA损伤位点，并通过敲低实验证明其调控BRCA1复合体的招募。
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3. **文献名称**: *Characterization of SENP7 antibody specificity in stem cell differentiation*
**作者**: Yeh ETH, et al.
**摘要**: 开发并验证了一种高特异性SENP7单克隆抗体，用于检测其在胚胎干细胞分化过程中的表达变化。通过质谱和敲除细胞系验证抗体特异性，并发现SENP7通过调控组蛋白SUMO化影响多能性基因沉默。
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如需真实文献，建议在PubMed或Google Scholar检索关键词：**SENP7 antibody** + **SUMO protease**/**chromatin**/**DNA repair**。
SENP7 (Sentrin-specific protease 7) is a member of the SUMO (Small Ubiquitin-like Modifier)-specific protease family, which plays a critical role in regulating SUMOylation, a reversible post-translational modification involved in diverse cellular processes. Unlike other SENP proteases that primarily process SUMO precursors or deconjugate SUMO from substrates, SENP7 exhibits unique substrate specificity, preferentially cleaving poly-SUMO chains and targeting SUMOylated proteins in chromatin-associated complexes. It is implicated in maintaining genomic stability, transcriptional regulation, and heterochromatin organization by interacting with proteins like HP1 (heterochromatin protein 1) and ATRX.
SENP7 antibodies are essential tools for studying its expression, localization, and molecular interactions. These antibodies are typically developed using immunogenic peptides or recombinant protein fragments and validated for specificity through techniques like Western blotting, immunofluorescence, or knockout cell line controls. Researchers employ SENP7 antibodies to investigate its involvement in diseases such as cancer, where dysregulated SUMOylation impacts tumor progression, or neurological disorders linked to chromatin remodeling defects. Challenges in antibody development include cross-reactivity with other SENP family members due to structural similarities, necessitating rigorous validation. Current studies focus on elucidating SENP7's role in DNA repair, stem cell differentiation, and epigenetic regulation, highlighting its therapeutic potential.
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