| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | SA2; SA-2; SCC3B; bA517O1.1 |
| WB Predicted band size | 141 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human STAG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STAG2抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Recurrent Loss of STAG2 in Bladder Cancer*
**作者**：Solomon DA et al.
**摘要**：该研究通过免疫组化(IHC)和Western blot分析，发现STAG2在非肌层侵袭性膀胱癌中频繁突变或表达缺失，提示其作为肿瘤抑制因子的作用。研究使用特异性STAG2抗体验证了蛋白表达缺失与基因突变的关联。
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2. **文献名称**：*Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer*
**作者**：Lawrence MS et al.
**摘要**：文章通过全外显子测序和抗体检测(IHC/WB)，揭示了STAG2在多种癌症(如胶质母细胞瘤、黑色素瘤)中的高频失活突变，其缺失导致染色体不稳定性，促进肿瘤发生。
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3. **文献名称**：*STAG2 Mutations Alter Cohesin-DNA Biology in Acute Myeloid Leukemia*
**作者**：Kon A et al.
**摘要**：研究利用CRISPR-Cas9和STAG2抗体进行功能实验，发现STAG2突变破坏粘连蛋白复合体与DNA的相互作用，影响造血干细胞的增殖分化，与急性髓系白血病(AML)的进展相关。
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**备注**：以上文献为示例，实际引用时需核对作者、期刊和年份的准确性。建议通过PubMed或Google Scholar以关键词“STAG2 antibody”或“STAG2 cohesin cancer”检索最新研究。
The STAG2 antibody targets the STAG2 protein, a core subunit of the cohesin complex, which regulates chromosome organization, sister chromatid cohesion, and transcriptional regulation. STAG2 partners with other cohesin components (SMC1. SMC3. RAD21) to form a ring-like structure that encircles DNA, ensuring genomic stability during cell division. Mutations in the *STAG2* gene are recurrently observed in cancers, including myeloid malignancies (e.g., acute myeloid leukemia), urothelial carcinoma, and glioblastoma, often linked to aneuploidy and poor prognosis. STAG2 loss is associated with impaired DNA repair, altered chromatin looping, and dysregulated gene expression.
STAG2 antibodies are widely used in research to study cohesin function, detect STAG2 expression levels in cancer models, and explore its role in tumorigenesis. These tools enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein localization, expression loss in mutant cells, or cohesin complex dynamics. Some antibodies specifically recognize distinct STAG2 isoforms or post-translational modifications. Validation is critical, as STAG2 shares homology with STAG1/STAG3. and nonspecific binding may occur. Recent studies also investigate STAG2's potential as a therapeutic target or biomarker for precision oncology, driving demand for reliable antibodies in translational research.
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