| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ATX1; HAH1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ATOX1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ATOX1抗体的参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库验证)：
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1. **"The copper chaperone ATOX1 regulates copper homeostasis in mammalian cells"**
*Hamza I, Prohaska J, Gitlin JD*
摘要：本研究利用特异性ATOX1抗体，揭示了ATOX1在哺乳动物细胞铜稳态中的关键作用。通过免疫荧光和Western blot分析，发现ATOX1与威尔逊病蛋白ATP7B在高尔基体的相互作用，调控细胞内铜的转运与分布。
2. **"ATOX1: A novel copper chaperone involved in cancer progression"**
*Mattiello T, et al.*
摘要：通过ATOX1抗体检测多种癌症细胞系及肿瘤组织，发现ATOX1在乳腺癌和结肠癌中显著高表达，并与患者预后不良相关。研究提示其可能作为癌症治疗的潜在靶点。
3. **"Neuronal copper chaperone ATOX1 protects against oxidative stress in Alzheimer's disease"**
*Hung YH, et al.*
摘要：采用ATOX1抗体进行免疫组化分析，发现阿尔茨海默病患者脑组织中ATOX1表达水平降低，表明其抗氧化功能受损可能与疾病进展相关。
4. **"Antibody-based detection of ATOX1 in Wilson disease models"**
*Hatori Y, et al.*
摘要：研究开发并验证了一种高特异性ATOX1多克隆抗体，应用于威尔逊病模型小鼠的肝组织分析，揭示了ATOX1在铜转运缺陷中的代偿性表达上调。
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**注意**：以上文献信息为示例性质，实际引用时需通过PubMed、Web of Science等平台检索真实文献，并核对作者、标题及摘要准确性。
The ATOX1 (Antioxidant 1) antibody is a tool used to detect and study the ATOX1 protein, a copper chaperone critical for maintaining cellular copper homeostasis. ATOX1 facilitates the transfer of copper ions to ATP7A and ATP7B, transmembrane transporters responsible for copper efflux and incorporation into cuproenzymes. Dysregulation of copper metabolism, linked to ATOX1 dysfunction, is associated with disorders like Wilson disease and Menkes disease. ATOX1 also exhibits antioxidant properties, protecting cells from oxidative stress by scavenging free radicals.
Research using ATOX1 antibodies has revealed its involvement in diverse biological processes, including cell proliferation, DNA repair, and transcriptional regulation. In cancer, elevated ATOX1 levels correlate with tumor progression and metastasis in breast, colorectal, and other cancers, suggesting its role in promoting oncogenic signaling. Structurally, ATOX1 forms homodimers and interacts with copper via a conserved CXXC motif.
ATOX1 antibodies are widely applied in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein expression, localization, and post-translational modifications. These studies help elucidate ATOX1’s regulatory mechanisms in copper-dependent pathways and its potential as a therapeutic target. Recent work also explores its involvement in neurodegenerative diseases, where copper imbalance contributes to pathology. Overall, ATOX1 antibodies are vital for advancing understanding of copper biology and related diseases.
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