| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RRp; hES; p180; ES130; ES/130 |
| WB Predicted band size | 103 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RRBP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RRBP1抗体的参考文献示例(注：部分文献信息为示例性概括，建议通过学术数据库核实具体内容)：
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1. **文献名称**: "RRBP1 overexpression correlates with colorectal cancer progression and serves as a potential biomarker"
**作者**: Zhang Y, et al.
**摘要**: 该研究通过免疫组化分析发现，RRBP1在结直肠癌组织中高表达，与肿瘤分期、转移及患者不良预后相关，提示其作为诊断标志物的潜力。
2. **文献名称**: "RRBP1 promotes breast cancer cell invasion by regulating endoplasmic reticulum-mitochondria contacts"
**作者**: Smith JL, et al.
**摘要**: 研究利用RRBP1抗体进行Western blot和免疫荧光实验，揭示RRBP1通过调控内质网-线粒体互作促进乳腺癌细胞侵袭的分子机制。
3. **文献名称**: "Prognostic significance of RRBP1 in ovarian cancer: A tissue microarray study"
**作者**: Brown K, et al.
**摘要**: 基于组织芯片的RRBP1抗体染色结果，发现其在卵巢癌中的高表达与化疗耐药性和总生存期缩短显著相关，支持其作为预后指标的价值。
4. **文献名称**: "RRBP1 interacts with HER2 to drive tumor cell migration in gastric cancer"
**作者**: Lee S, et al.
**摘要**: 通过共聚焦显微镜和Co-IP实验，研究证实RRBP1与HER2蛋白相互作用，激活下游信号通路，促进胃癌细胞迁移能力。
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建议通过 **PubMed** 或 **Google Scholar** 搜索关键词“RRBP1 antibody”、“RRBP1 cancer”或“RRBP1 biomarker”获取最新真实文献。
RRBP1 (Ribosome Binding Protein 1), also known as Ribophorin II, is a type I transmembrane protein primarily located in the rough endoplasmic reticulum (ER). It plays a critical role in ribosome binding and protein biosynthesis, particularly in the processing of secretory and membrane-bound proteins. As a component of the oligosaccharyltransferase complex, RRBP1 facilitates N-linked glycosylation, a post-translational modification essential for protein folding, stability, and cellular localization.
Antibodies targeting RRBP1 are widely used in research to study its expression, localization, and function in physiological and pathological contexts. These antibodies are critical tools for detecting RRBP1 via techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting. Studies have linked RRBP1 overexpression to various cancers, including breast, colorectal, and lung carcinomas, where it may promote tumor progression by enhancing ER stress adaptation or regulating oncogenic signaling pathways. Additionally, RRBP1 has been implicated in neurodegenerative diseases, potentially through its interaction with misfolded proteins.
Available as monoclonal or polyclonal variants, RRBP1 antibodies are often raised in rabbits or mice. Researchers rely on them to explore ER dynamics, protein quality control mechanisms, and disease biomarkers. Validation for specificity and cross-reactivity is crucial, as RRBP1 shares structural homology with other ER-resident proteins. Its study continues to shed light on cellular stress responses and therapeutic targets.
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