| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DjB4; HLJ1; DNAJW |
| WB Predicted band size | 38 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human DNAJB4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DNAJB4抗体的3篇参考文献示例(文献信息为模拟概括，仅供参考)：
1. **文献名称**：DNAJB4 suppresses tumor progression via inhibiting EMT in colorectal cancer
**作者**：Zhang Y, et al.
**摘要**：该研究通过DNAJB4抗体检测发现，DNAJB4在结直肠癌中低表达，其过表达可通过抑制上皮间质转化(EMT)降低癌细胞侵袭能力，提示其作为肿瘤抑制因子的作用。
2. **文献名称**：DNAJB4 interacts with tau protein in neurodegenerative models
**作者**：Choi J, et al.
**摘要**：利用DNAJB4抗体进行免疫共沉淀实验，证明DNAJB4作为分子伴侣与错误折叠的tau蛋白相互作用，可能参与阿尔茨海默病中蛋白聚集的调控。
3. **文献名称**：Hypoxia-induced downregulation of DNAJB4 promotes breast cancer metastasis
**作者**：Liu X, et al.
**摘要**：通过免疫组化(使用DNAJB4抗体)发现，低氧微环境导致乳腺癌细胞中DNAJB4表达下调，进而激活Hippo信号通路，促进肿瘤转移，其低表达与患者不良预后相关。
4. **文献名称**：DNAJB4 as a stress-responsive marker in ER stress pathways
**作者**：Xu L, et al.
**摘要**：研究利用Western blot(基于DNAJB4抗体)揭示，内质网应激可诱导DNAJB4表达上调，其可能通过调控IRE1α通路参与细胞应激适应性反应。
(注：以上为模拟生成内容，实际文献需通过数据库如PubMed确认。)
The DNAJB4 antibody is a tool used to detect DNAJB4. a member of the heat shock protein 40 (Hsp40/DNAJ) family. DNAJB4. also known as HLJ1. functions as a co-chaperone for Hsp70 proteins, aiding in protein folding, preventing aggregation, and facilitating cellular stress responses. It plays roles in apoptosis, autophagy, and cancer progression, with studies linking its expression to tumor suppression, metastasis inhibition, and chemoresistance modulation.
DNAJB4 is epigenetically regulated and often downregulated in cancers (e.g., lung, colorectal, breast) due to promoter hypermethylation. Its loss correlates with poor prognosis, while overexpression can impair cancer cell invasion. These features make DNAJB4 a potential biomarker or therapeutic target.
The DNAJB4 antibody is widely used in techniques like Western blot, immunohistochemistry (IHC), and immunofluorescence (IF) to study its expression patterns, subcellular localization, and interactions in both normal and diseased tissues. Researchers employ it to explore DNAJB4’s role in stress adaptation, cancer biology, and neurodegenerative disorders, where protein misfolding is implicated. Commercial antibodies are typically validated for specificity and sensitivity across species (human, mouse, rat), supporting translational and mechanistic studies.
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