关键信息
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基因名
Testican 3/SPOCK3
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简介
The Testican 3/SPOCK3 protein may be involved in different steps of neurogenesis, suggesting a multifaceted role in neuronal cell development. It inhibits pro-matrix metalloproteinase 2 (MMP-2) processing through MT1-MMP and MT3-MMP and regulates MMP-2 activity. Testican 3/SPOCK3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Testican 3/SPOCK3 protein, expressed by HEK293 , with C-6*His labeled tag.
- 应用
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别名
Testican-3; Spock3
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种属
Mouse
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8BKV0-1
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表达区间
A23-I436
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氨基酸序列
AAAVAVAGGRSDGGNFLDEKQWLTTISQYDKEVGQWNKFRDEVEDDYFRTWNPGKPFDQALDPAKDPCLKTKCSRHKVCITQDAQTALCISHRRLTHSMKEVGGSHKQWRGLPSSTCKPCPIAYASPVCGSDGHSYSSQCKLEYQACVLGKQISIKCEGRCPCPSDKSMNIGRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKALLRPERSRFDTSILPICKDSLGWMFNRLDTNYDLLLDQSELGSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCHTELSNIQKRQGIKKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVADCAIDFEISGDFASGDFREWTDDEGEEDDIMNDKDDIEDDDEDEGDDDDDGDVHDGYI
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
58-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Testican 3, also known as SPOCK3, is a member of the SPOCK family of proteins that play crucial roles in various physiological processes, including cell adhesion, migration, and the regulation of extracellular matrix components. The importance of Testican 3 has been highlighted in multiple studies, particularly due to its involvement in cancer progression and neural development. Research indicates that Testican 3 may act as a modulator in tumor microenvironments, influencing cancer cell behavior and the interaction with surrounding stromal cells. Additionally, its expression patterns are often altered in various malignancies, suggesting a potential role as a biomarker for certain cancers. Despite its significance, the biochemical properties and functional mechanisms of Testican 3 remain largely underexplored. This gap in knowledge has prompted researchers to focus on the recombinant expression of Testican 3 to elucidate its structure and function. By producing a recombinant version of this protein, scientists aim to investigate its interactions with other cellular components and to better understand its roles in normal and pathological conditions. Overall, the study of Testican 3/SPOCK3 not only advances our understanding of its biological functions but also holds promise for developing novel therapeutic strategies targeting its pathways in cancer and other diseases.
