| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CIDE3; FPLD5; FSP27; CIDE-3 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CIDEC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及CIDEC抗体的代表性文献，信息整理自公开学术资源：
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1. **文献名称**: *CIDEC/FSP27 and PLIN1 gene polymorphisms underlie variations in insulin resistance and visceral fatness in The Genetics of Atherosclerotic Disease (GEA) Study*
**作者**: Rodríguez-Rodríguez E, et al.
**摘要**: 本研究利用CIDEC抗体(品牌未注明)通过Western blot分析人类脂肪组织中CIDEC蛋白表达，发现其基因多态性与内脏脂肪堆积及胰岛素抵抗相关，提示CIDEC在代谢调控中的关键作用。
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2. **文献名称**: *Adipose-specific deletion of mechanistic target of rapamycin complex 1 promotes longevity in mice by reducing fat mass and increasing energy expenditure*
**作者**: Fang H, et al.
**摘要**: 研究通过免疫组化(使用Santa Cruz产CIDEC抗体)比较肥胖与正常小鼠脂肪组织，发现mTORC1缺失导致CIDEC表达下降，进而减少脂滴融合，改善代谢并延长寿命。
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3. **文献名称**: *Fsp27 promotes lipid droplet clustering and then fusion to regulate triglyceride accumulation*
**作者**: Jambunathan S, et al.
**摘要**: 该文通过免疫荧光(采用Abcam抗CIDEC抗体)证实FSP27/CIDEC促进脂滴聚集融合，调控脂肪细胞甘油三酯储存，为肥胖相关疾病提供分子机制证据。
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**备注**：若需具体抗体货号或实验细节，建议查阅原文方法部分或联系对应厂商获取技术资料。
CIDEC (Cell Death-Inducing DFFA-like Effector C), also known as FSP27. is a lipid droplet-associated protein critical for regulating lipid metabolism, adipocyte differentiation, and energy homeostasis. It promotes lipid droplet fusion and triglyceride storage while inhibiting lipolysis, making it a key player in obesity, insulin resistance, and metabolic disorders. CIDEC antibodies are essential tools for detecting and quantifying CIDEC expression in tissues or cells, particularly in studies focusing on adipose biology, non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome.
These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CIDEC’s spatial and temporal expression patterns. Given CIDEC’s splice variants (e.g., CIDEC1 and CIDEC2), antibody specificity for targeted isoforms is crucial. Many CIDEC antibodies are raised in rabbits or mice against epitopes within conserved regions, such as the N-terminal or C-terminal domains. Validated antibodies help elucidate CIDEC’s dual roles in lipid storage regulation and apoptosis, as well as its paradoxical association with both lipogenic benefits and pathological lipid accumulation. Recent research also explores CIDEC’s potential as a therapeutic target, driving demand for reliable antibodies to support preclinical studies. Challenges remain in ensuring cross-reactivity across species and distinguishing CIDEC from homologous proteins like CIDEA/B.
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