关键信息
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基因名
Meprin alpha/MEP1A
- 应用
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别名
PPHA; PABA Peptide Hydrolase; Endopeptidase-2; N-benzoyl-L-tyrosyl-P-amino-Benzoic Acid Hydrolase Subunit Alpha; PABA Peptide Hydrolase
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q16819
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表达区间
His213~Val506
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分子量
39kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
Meprin alpha, encoded by the MEP1A gene, is a metalloendopeptidase that belongs to the astacin family of proteases. It is widely expressed in various tissues, particularly in the kidneys and intestines, and plays a crucial role in extracellular matrix remodeling, immune response modulation, and protein processing. Dysregulation of Meprin alpha has been implicated in several pathological conditions, including renal diseases, inflammation, and cancer. The enzyme’s ability to cleave a diverse range of substrates makes it a significant player in many biological processes. Research has increasingly focused on recombinant forms of Meprin alpha (rMeprin alpha) to better understand its functional mechanisms and potential therapeutic applications. By producing rMeprin alpha, scientists aim to investigate its substrate specificity, catalytic activity, and interaction with other proteins. Furthermore, recombinant proteins can be utilized in drug development, enabling the design of inhibitors that could mitigate the enzyme’s pathological effects in diseases. Overall, the study of recombinant Meprin alpha presents promising opportunities for advancing our understanding of its biological roles and therapeutic potential.
