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Rabbit Polyclonal HIPK4 Antibody

  • 中文名: HIPK4抗体
  • 别    名: nan
货号: IPDX01023
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesA2MD; CPAMD5; FWP007; S863-7
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human A2M
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于HIPK4抗体的参考文献示例(注:以下内容为虚构,仅供格式参考,实际文献需通过学术数据库检索获取):

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1. **文献名称**:*HIPK4 regulates spermatogenesis through kinase activity and interaction with heat shock proteins*

**作者**:Wang, Y. et al.

**摘要**:本研究利用特异性抗HIPK4的多克隆抗体,揭示了HIPK4在小鼠精子形成中的关键作用。通过免疫组化和Western blot分析,发现HIPK4与热休克蛋白HSP90相互作用,调控精子细胞分化过程中的蛋白质稳态。

2. **文献名称**:*Development of a monoclonal antibody targeting human HIPK4 for cancer biomarker studies*

**作者**:Chen, L. et al.

**摘要**:研究团队开发了一种针对人源HIPK4的单克隆抗体,并通过免疫沉淀和质谱验证其特异性。该抗体在结直肠癌组织样本中检测到HIPK4的异常高表达,提示其作为潜在肿瘤标志物的可能性。

3. **文献名称**:*HIPK4 deficiency disrupts ciliogenesis in mammalian cells*

**作者**:Garcia, R. et al.

**摘要**:通过CRISPR/Cas9敲除结合HIPK4抗体检测,证实HIPK4在纤毛形成中的作用。研究显示,HIPK4缺失导致纤毛结构缺陷,并影响Hedgehog信号通路。

4. **文献名称**:*A novel role of HIPK4 in neuronal stress response pathways*

**作者**:Kim, S. et al.

**摘要**:使用抗HIPK4抗体进行免疫荧光染色,发现HIPK4在神经元应激颗粒中富集。进一步实验表明,HIPK4通过磷酸化下游蛋白参与氧化应激反应的调控。

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建议通过PubMed、Google Scholar等平台以“HIPK4 antibody”、“HIPK4 kinase function”为关键词检索真实文献。

背景信息

HIPA antibody targets Homeodomain-Interacting Protein Kinase 4 (HIPK4), a member of the HIPK family of serine/threonine kinases involved in diverse cellular processes, including DNA damage response, transcriptional regulation, and apoptosis. HIPK4. less characterized compared to HIPK1-3. shares a conserved kinase domain but exhibits distinct structural features, such as a unique N-terminal region and lack of a homodimerization domain. It is predominantly expressed in the testis, suggesting a specialized role in spermatogenesis, particularly in chromatin condensation and meiotic progression. Studies link HIPK4 dysfunction to male infertility due to impaired sperm maturation. HIPK4 antibodies are essential tools for detecting HIPK4 expression, localization, and interaction partners in research. They enable investigations into its kinase activity, substrate specificity, and regulatory mechanisms using techniques like Western blot, immunohistochemistry, and immunofluorescence. Recent work highlights HIPK4's potential involvement in cancer and neurodegenerative diseases, though its precise molecular pathways remain unclear. Reliable HIPK4 antibodies aid in elucidating its biological significance and therapeutic potential, addressing gaps in understanding its context-dependent roles and signaling networks.

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