| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | SERPINB14 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Chicken |
| Immunogen | OVAL protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZWINT抗体的参考文献示例(注：以下为虚拟示例，实际文献请通过学术数据库查询)：
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1. **文献名称**: "ZWINT as a prognostic biomarker in hepatocellular carcinoma: immunohistochemical analysis"
**作者**: Li X, et al.
**摘要**: 研究通过免疫组化(使用ZWINT抗体)检测ZWINT在肝细胞癌中的表达，发现其高表达与肿瘤分期及不良预后显著相关，提示ZWINT可能作为肝癌的潜在生物标志物。
2. **文献名称**: "Role of ZWINT in mitotic regulation and its interaction with the kinetochore complex"
**作者**: Smith J, et al.
**摘要**: 利用ZWINT抗体进行Western blot和免疫荧光实验，发现ZWINT通过与动粒蛋白复合体相互作用调控有丝分裂进程，其缺失会导致染色体排列异常。
3. **文献名称**: "Overexpression of ZWINT promotes breast cancer progression via PI3K/AKT signaling"
**作者**: Wang Y, et al.
**摘要**: 研究通过siRNA敲低和ZWINT抗体检测发现，ZWINT通过激活PI3K/AKT通路促进乳腺癌细胞增殖和侵袭，为治疗靶点提供依据。
4. **文献名称**: "Clinical significance of ZWINT expression in colorectal cancer patients"
**作者**: Chen R, et al.
**摘要**: 分析结直肠癌组织中ZWINT蛋白水平(采用抗体ELISA法)，发现其表达与淋巴结转移和生存率下降相关，提示其作为预后指标的潜力。
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实际文献需通过 **PubMed**、**Web of Science** 或 **Google Scholar** 等平台，以关键词“ZWINT antibody”、“ZWINT cancer”等检索获取。
ZWINT (Zeste White 10 Interacting Protein) is a protein involved in mitotic checkpoint regulation and kinetochore assembly during cell division. Initially identified through its interaction with ZW10. a component critical for proper chromosome segregation, ZWINT plays a crucial role in maintaining genomic stability by ensuring accurate microtubule-kinetochore attachments and spindle assembly checkpoint signaling. It associates with the MIS12 complex, facilitating kinetochore recruitment of other checkpoint proteins like Zwilch and Rod. Dysregulation of ZWINT has been linked to chromosomal instability, aneuploidy, and tumorigenesis, with overexpression observed in various cancers, suggesting its potential as a biomarker or therapeutic target.
ZWINT antibodies are essential tools for studying these biological processes. They enable the detection, localization, and quantification of ZWINT in experimental models, including Western blotting, immunofluorescence, and immunohistochemistry. Such antibodies help elucidate ZWINT's role in cell cycle dynamics, its interaction networks, and its pathological implications in cancer. Commercial ZWINT antibodies are typically raised against specific epitopes, with validation in knock-down or knock-out models to ensure specificity. Research using these antibodies continues to advance understanding of mitotic errors and their contribution to disease, bridging basic cell biology and clinical oncology.
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