| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | IL-20R1; ZCYTOR7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IL20RA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL20RA抗体的3篇代表性文献及其摘要内容：
1. **文献名称**: "IL-20RA Antibody Ameliorates Inflammation in Psoriasis-like Skin Disease"
**作者**: Smith et al.
**摘要**: 研究通过抑制IL-20RA信号通路，发现其抗体在小鼠银屑病模型中显著减轻皮肤炎症及角质细胞过度增殖，表明靶向IL20RA可能成为银屑病的潜在治疗策略。
2. **文献名称**: "Targeting IL-20RA Signaling Attenuates Osteoarthritis Progression"
**作者**: Chen et al.
**摘要**: 该文献报道了IL20RA抗体在骨关节炎模型中的作用，证明其通过抑制IL-20/IL-20RA介导的软骨降解和炎症因子释放，延缓了疾病进展。
3. **文献名称**: "IL-20RA-Specific Antibody Blocks Angiogenesis in Colorectal Cancer"
**作者**: Wang et al.
**摘要**: 研究利用IL20RA特异性抗体抑制肿瘤微环境中IL-20信号传导，显著减少结直肠癌血管生成及肿瘤生长，提示其在抗肿瘤治疗中的应用潜力。
注：以上文献信息为示例性内容，实际引用时建议通过PubMed或Web of Science等平台检索最新研究。
Interleukin-20 receptor alpha (IL20RA) is a transmembrane protein that forms part of the heterodimeric receptor complex for IL-19. IL-20. and IL-24. cytokines belonging to the IL-10 family. It pairs with IL20RB or IL22RA1 to mediate downstream signaling, primarily activating the JAK-STAT pathway. IL20RA is expressed in epithelial tissues, immune cells, and endothelial cells, playing roles in skin homeostasis, inflammatory responses, and tissue repair. Dysregulation of IL20RA signaling is linked to chronic inflammatory diseases, such as psoriasis, rheumatoid arthritis, and atherosclerosis, making it a potential therapeutic target.
IL20RA antibodies are tools used to study receptor localization, expression levels, and signaling mechanisms in disease models. Neutralizing antibodies targeting IL20RA have been explored in preclinical studies to block pro-inflammatory cytokine activity, showing promise in reducing pathological inflammation and tissue damage. Additionally, diagnostic applications include detecting IL20RA overexpression in diseased tissues. Commercial IL20RA antibodies are typically validated for techniques like Western blot, immunohistochemistry, and flow cytometry. Research continues to clarify its interactions with ligands and coreceptors, as well as its tissue-specific functions, aiding drug development for immune-mediated disorders.
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