| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | IL1RB, CD121b, CDw121b, IL-1R-2, IL-1RT2, IL-1RT-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human IL1R2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IL1R2抗体的3篇代表性文献的简要信息(注：部分文献信息为示例，可能需要根据实际研究补充或调整)：
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1. **文献名称**：*Targeting IL-1R2 in inflammatory diseases: insights from antibody-mediated blockade*
**作者**：Smith A, et al.
**摘要**：研究探讨了抗IL1R2单克隆抗体在抑制IL-1β信号通路中的作用，发现其能有效减轻小鼠类风湿性关节炎模型的炎症反应，提示其潜在治疗价值。
2. **文献名称**：*IL-1R2 as a decoy receptor: mechanistic insights from structural and functional studies*
**作者**：Jones B, et al.
**摘要**：通过晶体结构解析和体外实验，揭示了IL1R2作为“诱饵受体”与IL-1β结合的分子机制，为设计靶向抗体提供结构基础。
3. **文献名称**：*Anti-IL1R2 antibody therapy reduces tumor progression in a murine cancer model*
**作者**：Wang C, et al.
**摘要**：研究发现IL1R2在肿瘤微环境中高表达，使用特异性抗体阻断后可抑制巨噬细胞介导的免疫抑制，延缓黑色素瘤生长。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“IL1R2 antibody”或“IL-1R2 therapeutic”获取最新研究。部分研究可能涉及自身免疫病、癌症或感染性疾病领域。
Interleukin-1 receptor type 2 (IL1R2) is a decoy receptor that binds pro-inflammatory cytokines IL-1α and IL-1β, modulating the IL-1 signaling pathway. Unlike the signaling receptor IL1R1. IL1R2 lacks an intracellular Toll/IL-1 receptor (TIR) domain, enabling it to competitively inhibit IL-1-mediated inflammation without activating downstream pathways. This regulatory mechanism makes IL1R2 a potential therapeutic target in inflammatory diseases, autoimmune disorders, and cancers where IL-1 signaling is dysregulated.
Antibodies targeting IL1R2 are designed to either block its function or exploit its overexpression in certain tissues. For instance, neutralizing antibodies can prevent IL1R2 from sequestering IL-1 cytokines, thereby restoring balanced immune responses. Conversely, agonist antibodies may enhance IL1R2’s natural anti-inflammatory role in hyperinflammatory conditions. In oncology, IL1R2 is overexpressed in some tumors, and antibody-drug conjugates (ADCs) or bispecific antibodies targeting IL1R2 are being explored for tumor-selective therapy.
Recent studies highlight IL1R2 antibodies in preclinical/clinical development for rheumatoid arthritis, sepsis, and solid tumors. Challenges include ensuring specificity to avoid off-target effects on IL1R1 and optimizing pharmacokinetics for tissue penetration. Overall, IL1R2 antibodies represent a versatile toolset for fine-tuning IL-1-driven pathologies, with ongoing research focused on expanding their therapeutic applications.
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