| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FVH; IL18BPa |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human IL18BP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的关于IL-18BP抗体的参考文献示例(非真实文献，仅供参考)：
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1. **《IL-18 Binding Protein as a Therapeutic Target in Autoimmune Diseases》**
作者：Smith A, et al.
摘要：研究探讨了重组IL-18BP抗体在类风湿性关节炎和红斑狼疮模型中的治疗效果，证明其通过中和IL-18炎性通路减轻组织损伤和炎症反应。
2. **《Structural Characterization of IL-18BP and Its Neutralizing Antibodies》**
作者：Zhang L, et al.
摘要：通过X射线晶体学解析IL-18BP与其单克隆抗体的复合物结构，揭示了抗体阻断IL-18与受体结合的关键表位，为优化抗体药物设计提供依据。
3. **《Development of a High-Sensitivity ELISA for IL-18BP Detection》**
作者：Tanaka K, et al.
摘要：开发了一种基于单克隆抗体的高灵敏度ELISA检测方法，用于定量血清中IL-18BP水平，验证其在脓毒症患者中的临床诊断价值。
4. **《IL-18BP Antibodies in Viral Infection: Role in Modulating Cytokine Storms》**
作者：Wang X, et al.
摘要：研究IL-18BP抗体在流感病毒感染模型中的作用，发现其通过调节IL-18/IL-18BP平衡抑制过度炎症反应，降低细胞因子风暴风险。
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建议通过PubMed、Google Scholar等平台检索真实文献，关键词如“IL-18BP antibody”、“interleukin-18 binding protein therapeutics”等。
Interleukin-18 binding protein (IL18BP) is a soluble decoy receptor that specifically neutralizes the pro-inflammatory cytokine IL-18 by preventing its interaction with cell surface receptors. IL-18. a member of the IL-1 cytokine family, plays a key role in inflammatory and immune responses, particularly by inducing interferon-gamma (IFN-γ) production and promoting Th1-mediated immunity. Dysregulated IL-18 signaling is linked to autoimmune disorders (e.g., rheumatoid arthritis, lupus), inflammatory diseases, and certain cancers. IL18BP, naturally produced by the body, acts as a critical regulatory mechanism to control excessive IL-18 activity.
IL18BP antibodies are tools developed to detect, quantify, or modulate IL18BP in research and therapeutic contexts. In research, these antibodies enable the study of IL18BP expression patterns, interactions with IL-18. and its role in disease models. Therapeutically, recombinant IL18BP or IL18BP-targeting antibodies are explored to either enhance IL-18 neutralization (e.g., in cytokine storm syndromes) or block IL18BP to boost IL-18-driven anti-tumor immunity in cancer immunotherapy. Monoclonal antibodies against IL18BP are designed for high specificity, with some in preclinical development for inflammatory and oncological indications. Challenges include optimizing binding affinity and understanding tissue-specific IL18BP dynamics. Overall, IL18BP antibodies represent a promising avenue for modulating IL-18 pathways in immune-related diseases.
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