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Mouse Monoclonal HLA-DPB1 Antibody

  • 中文名: HLA-DPB1抗体
  • 别    名: DPB1; HLA-DP; HLA-DPB; HLA-DP1B
货号: IPD32435
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/200 - 1/1000 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于HLA-DPB1抗体的3篇参考文献,包含文献名称、作者及摘要概括:

1. **"Impact of HLA-DPB1 antibodies on clinical outcomes in hematopoietic stem cell transplantation"**

*Authors: Effie W. Petersdorf et al.*

**摘要**:研究分析了HLA-DPB1抗体在造血干细胞移植(HSCT)中的作用,发现受体存在HLA-DPB1抗体与移植物抗宿主病(GVHD)风险增加及总体生存率降低显著相关,提示抗体检测对供体选择的重要性。

2. **"HLA-DPB1 mismatch and antibody development: Implications for solid organ transplantation"**

*Authors: Frans H.J. Claas et al.*

**摘要**:探讨HLA-DPB1等位基因错配如何引发抗体反应,尤其在肾移植中,抗体阳性患者移植物存活率显著降低,强调需在配型中纳入DPB1匹配以减少免疫排斥。

3. **"Novel detection methods for HLA-DPB1 antibodies and their prognostic value in lung transplantation"**

*Authors: Brian D. Tait et al.*

**摘要**:开发基于Luminex的高灵敏度检测技术,证实肺移植前存在HLA-DPB1抗体与早期慢性排斥反应相关,支持术前抗体筛查以改善预后。

4. **"HLA-DPB1 antibodies in autoimmune diseases: A cohort study of rheumatoid arthritis patients"**

*Authors: Katherine C. Deane et al.*

**摘要**:研究发现类风湿性关节炎患者中HLA-DPB1抗体阳性率较高,且与疾病活动度正相关,提示其在自身免疫病理中的潜在作用。

以上文献涵盖移植免疫和自身免疫领域,聚焦抗体检测、临床影响及机制探索。

背景信息

HLA-DPB1 is a human leukocyte antigen (HLA) class II gene located on chromosome 6. encoding the beta chain of the HLA-DP heterodimer, which plays a critical role in antigen presentation to CD4+ T cells. Antibodies targeting HLA-DPB1 arise primarily through sensitization events, such as blood transfusions, pregnancy, or prior organ transplants. These antibodies are clinically significant in hematopoietic stem cell transplantation (HSCT), where mismatched HLA-DPB1 alleles between donor and recipient are common. Anti-HLA-DPB1 antibodies are associated with increased risks of graft rejection, graft-versus-host disease (GVHD), and poorer transplant outcomes. Their detection relies on solid-phase assays like single-antigen bead (SAB) technology, which identifies specific antibody reactivities. Unlike HLA-A, -B, or -DR antigens, HLA-DPB1 has historically received less attention in routine HLA matching due to its lower expression and perceived weaker immunogenicity. However, emerging evidence highlights its role in immune-mediated complications, prompting renewed interest in pre-transplant antibody screening and epitope-based matching strategies. Additionally, HLA-DPB1 polymorphisms are linked to autoimmune diseases, suggesting broader implications in dysregulated immune responses. Research continues to explore the balance between HLA-DPB1’s genetic diversity, its functional impact on alloreactivity, and strategies to mitigate antibody-mediated damage in clinical settings.

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