WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 1/200 - 1/400 | Human,Mouse,Rat |
Elisa | 1/10000 | Human,Mouse,Rat |
Aliases | DPB1; HLA-DP; HLA-DPB; HLA-DP1B |
Entrez GeneID | 3115 |
clone | 5C9F4 |
WB Predicted band size | 29.2kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Rat |
Immunogen | Purified recombinant fragment of human HLA-DPB1 (AA: extra 30-215) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于HLA-DPB1抗体的3篇参考文献,包含文献名称、作者及摘要概括:
1. **"Impact of HLA-DPB1 antibodies on clinical outcomes in hematopoietic stem cell transplantation"**
*Authors: Effie W. Petersdorf et al.*
**摘要**:研究分析了HLA-DPB1抗体在造血干细胞移植(HSCT)中的作用,发现受体存在HLA-DPB1抗体与移植物抗宿主病(GVHD)风险增加及总体生存率降低显著相关,提示抗体检测对供体选择的重要性。
2. **"HLA-DPB1 mismatch and antibody development: Implications for solid organ transplantation"**
*Authors: Frans H.J. Claas et al.*
**摘要**:探讨HLA-DPB1等位基因错配如何引发抗体反应,尤其在肾移植中,抗体阳性患者移植物存活率显著降低,强调需在配型中纳入DPB1匹配以减少免疫排斥。
3. **"Novel detection methods for HLA-DPB1 antibodies and their prognostic value in lung transplantation"**
*Authors: Brian D. Tait et al.*
**摘要**:开发基于Luminex的高灵敏度检测技术,证实肺移植前存在HLA-DPB1抗体与早期慢性排斥反应相关,支持术前抗体筛查以改善预后。
4. **"HLA-DPB1 antibodies in autoimmune diseases: A cohort study of rheumatoid arthritis patients"**
*Authors: Katherine C. Deane et al.*
**摘要**:研究发现类风湿性关节炎患者中HLA-DPB1抗体阳性率较高,且与疾病活动度正相关,提示其在自身免疫病理中的潜在作用。
以上文献涵盖移植免疫和自身免疫领域,聚焦抗体检测、临床影响及机制探索。
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