Mouse Monoclonal PDGFA Antibody

The platelet-derived growth factor alpha (PDGFA) antibody is a crucial tool in biomedical research for detecting and analyzing the PDGFA protein, a member of the platelet-derived growth factor (PDGF) family. PDGFA is a secreted signaling protein involved in cell proliferation, migration, survival, and tissue development. It functions by binding to its receptor, PDGFRα (platelet-derived growth factor receptor alpha), or PDGFRα/β heterodimers, activating downstream pathways like MAPK and PI3K/AKT, which regulate processes such as wound healing, angiogenesis, and embryogenesis. Dysregulation of PDGFA signaling is linked to pathologies including cancer, fibrosis, atherosclerosis, and inflammatory diseases. PDGFA antibodies are widely used in techniques like Western blotting, immunohistochemistry, ELISA, and flow cytometry to study protein expression, localization, and signaling dynamics in cell lines, tissues, or clinical samples. Researchers employ these antibodies to explore PDGFA's role in tumor progression, stromal interactions, and vascular remodeling, as well as to evaluate therapeutic targets. Specificity and validation (e.g., knockout controls) are critical to ensure accurate detection, given the structural similarities among PDGF family members. Commercial PDGFA antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the mature protein or precursor forms.