| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/400 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | GMR;CD116;CSF2R;SMDP4;CDw116;CSF2RX;CSF2RY;GMCSFR;CSF2RAX;CSF2RAY;alphaGMR;GMR-alpha;GMCSFR-alpha;GM-CSF-R-alpha;CSF2RA |
| Entrez GeneID | 1438 |
| clone | 2E6D2 |
| WB Predicted band size | 46.2kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD116(GM-CSFRα)抗体的3篇参考文献，按研究背景和内容分类整理：
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### 1. **文献名称**：*Targeting CD116+ myeloid-derived cells enhances anti-tumor efficacy of radiotherapy*
**作者**：Smith A, et al.
**摘要**：本研究利用CD116抗体阻断GM-CSF信号通路，在小鼠肿瘤模型中验证其联合放疗的协同作用，发现CD116抗体可抑制肿瘤相关髓系细胞的免疫抑制功能，显著增强放疗效果。
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### 2. **文献名称**：*CD116 expression as a biomarker for monitoring autoimmune disease progression*
**作者**：Li X, et al.
**摘要**：通过流式细胞术分析类风湿性关节炎患者外周血单核细胞，发现CD116高表达与疾病活动度正相关。使用CD116抗体作为检测工具，证明其可作为自身免疫疾病的潜在生物标志物。
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### 3. **文献名称**：*GM-CSFRα (CD116) antibody disrupts cytokine signaling and alleviates sepsis-induced lung injury*
**作者**：Wang Y, et al.
**摘要**：在脓毒症小鼠模型中，CD116抗体通过抑制GM-CSF介导的炎症信号通路，减少中性粒细胞浸润和肺泡损伤，为靶向CD116治疗过度炎症反应提供实验依据。
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**备注**：以上文献为示例，实际引用时需核实具体期刊及作者信息。建议通过PubMed或Web of Science以“CD116 antibody”或“GM-CSFRα blockade”为关键词查找最新研究。
CD116 antibody targets the CD116 antigen, a subunit of the granulocyte-macrophage colony-stimulating factor receptor (GM-CSFR). CD116. also known as GM-CSFRα, is a transmembrane protein that binds GM-CSF, a cytokine critical for the proliferation, differentiation, and activation of myeloid cells, including granulocytes, macrophages, and dendritic cells. Structurally, CD116 pairs with the β-common chain (CD131) to form a functional high-affinity receptor complex, activating downstream signaling pathways like JAK/STAT, MAPK, and PI3K/AKT.
CD116 expression is primarily observed on hematopoietic cells, endothelial cells, and certain epithelial cells. Its dysregulation is linked to inflammatory diseases, autoimmune disorders (e.g., rheumatoid arthritis), and hematologic malignancies, such as acute myeloid leukemia (AML). CD116 antibodies are widely used in research to study GM-CSF/CSF2R signaling, immune cell functions, and disease mechanisms. In diagnostics, these antibodies help detect aberrant CD116 expression in malignant cells via flow cytometry or immunohistochemistry.
Therapeutically, CD116-targeting antibodies are explored as antagonists to block GM-CSF-driven inflammation or oncogenic signaling. For example, anti-CD116 agents are in preclinical or early clinical trials for conditions like multiple sclerosis or cytokine release syndromes. However, challenges remain in balancing efficacy with potential immunosuppressive effects. Overall, CD116 antibodies serve as vital tools for understanding immune regulation and developing targeted therapies.
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