Mouse Monoclonal CD45R Antibody

The CD45R antibody targets specific isoforms of the CD45 molecule, a transmembrane tyrosine phosphatase expressed on all nucleated hematopoietic cells. CD45 (leukocyte common antigen) plays a critical role in regulating immune cell activation by modulating signaling through antigen receptors, such as the T-cell receptor (TCR) and B-cell receptor (BCR). Alternative splicing of CD45 exons generates multiple isoforms (e.g., CD45RA, CD45RB, CD45RC, CD45RO), distinguished by extracellular domain variations. CD45R antibodies specifically recognize these isoforms, enabling the identification of functionally distinct lymphocyte subsets. For example, CD45RA is associated with naïve T cells, while CD45RO marks antigen-experienced memory T cells. These antibodies are widely used in flow cytometry, immunohistochemistry, and immunoblotting to study immune cell differentiation, activation, and trafficking in health and disease. CD45R isoform expression patterns are also implicated in autoimmune disorders, immunodeficiency, and leukemia, making these antibodies valuable tools in both research and clinical diagnostics. Commercially available CD45R antibodies are often generated in rodents, with cross-reactivity validated in humans, mice, and other species. Their specificity and utility in delineating immune cell heterogeneity underscore their importance in immunology and translational medicine.