| WB | 1/500 - 1/2000 | Human, Monkey |
| IF | 咨询技术 | Human, Monkey |
| IHC | 1/200 - 1/1000 | Human, Monkey |
| ICC | 1/200 - 1/1000 | Human, Monkey |
| FCM | 1/200 - 1/400 | Human, Monkey |
| Elisa | 1/10000 | Human, Monkey |
| Aliases | LAMPA; CD107a; LGP120 |
| Entrez GeneID | 3916 |
| clone | 1D7C1 |
| WB Predicted band size | 44.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Monkey |
| Immunogen | Purified recombinant fragment of human LAMP1 (AA: 182-414) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于LAMP1抗体的3篇示例文献(注：以下内容为示例，实际文献需通过数据库检索获取)：
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1. **文献名称**：LAMP1 as a marker of lysosomal membrane dynamics in autophagy
**作者**：Eskelinen EL, et al.
**摘要**：研究利用LAMP1抗体追踪自噬过程中溶酶体膜的动态变化，发现LAMP1在自噬体与溶酶体融合中起关键作用，为自噬功能障碍相关疾病提供机制参考。
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2. **文献名称**：Role of LAMP1 in lysosomal exocytosis and immune response
**作者**：Huynh KK, et al.
**摘要**：通过LAMP1抗体检测发现，LAMP1蛋白参与溶酶体胞吐过程，调控抗原呈递和炎症反应，揭示了其在免疫缺陷疾病中的潜在病理作用。
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3. **文献名称**：LAMP1 deficiency disrupts lysosomal acidification and causes neurodegenerative pathology
**作者**：Saftig P, Klumperman J
**摘要**：利用LAMP1敲除模型及抗体标记，证明LAMP1缺失导致溶酶体酸化异常，引发神经元内蛋白聚集，与阿尔茨海默病等神经退行性疾病相关。
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4. **文献名称**：LAMP1 overexpression promotes cancer cell invasion via lysosomal protease secretion
**作者**：Binker-Cosen MJ, et al.
**摘要**：通过LAMP1抗体免疫组化分析，发现肿瘤细胞中LAMP1高表达促进溶酶体酶释放，增强细胞外基质降解能力，与癌症转移密切相关。
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建议通过PubMed、Google Scholar等平台，以“LAMP1 antibody”或“LAMP1 function”为关键词检索最新文献。
LAMP1 (Lysosome-Associated Membrane Protein 1) is a key transmembrane glycoprotein predominantly localized in lysosomal membranes and late endosomes. It plays a critical role in maintaining lysosomal integrity, pH regulation, and mediating autophagosome-lysosome fusion during autophagy. Structurally, LAMP1 features a heavily glycosylated luminal domain and a short cytoplasmic tail, which facilitates interactions with cytosolic proteins involved in vesicular trafficking.
Antibodies targeting LAMP1 are widely used as lysosomal markers in cellular and molecular biology research. They help visualize lysosomal distribution, track lysosome-related organelle dynamics, and study lysosomal dysfunction in diseases like cancer, neurodegenerative disorders (e.g., Alzheimer’s), and lysosomal storage diseases. Additionally, LAMP1 antibodies are employed to investigate pathogen-host interactions, as certain intracellular pathogens (e.g., *Myobacterium tuberculosis*, *Salmonella*) manipulate lysosomal pathways for survival.
In experimental workflows, LAMP1 antibodies are utilized in techniques such as immunofluorescence, Western blotting, and flow cytometry. Their specificity makes them valuable tools for distinguishing lysosomes from other vesicles (e.g., early endosomes marked by EEA1). However, interpretation requires caution due to potential cross-reactivity with LAMP2. a homologous protein sharing ~37% sequence identity. Recent studies also explore LAMP1’s role in extracellular vesicle biogenesis and immune modulation, expanding its biomedical relevance.
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