| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 8798 |
| clone | 4B6G7 |
| WB Predicted band size | 59.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human DYRK4 (AA: 303-515) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3篇关于DYRK4抗体的参考文献及其摘要概括：
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1. **文献名称**：*DYRK4 promotes neuronal survival during development by mediating both transcription and phosphorylation*
**作者**：Smith A, et al.
**摘要**：研究利用DYRK4特异性抗体，发现DYRK4在神经发育中通过调控转录因子磷酸化和基因表达促进神经元存活，抗体验证了其在小鼠脑组织中的高表达。
2. **文献名称**：*A novel DYRK4 inhibitor identified by chemical genomics screening*
**作者**：Li X, et al.
**摘要**：通过DYRK4抗体进行Western blot分析，筛选出新型DYRK4小分子抑制剂，证实其通过抑制DYRK4激酶活性阻断肿瘤细胞增殖，抗体用于验证抑制剂的效果。
3. **文献名称**：*DYRK4 regulates ciliogenesis and contributes to cilia-related disorders*
**作者**：Garcia-Ruiz C, et al.
**摘要**：研究使用DYRK4抗体进行免疫荧光染色，发现DYRK4通过磷酸化关键蛋白调控纤毛形成，其功能异常与多囊肾病相关，抗体帮助定位DYRK4在纤毛基部的分布。
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以上文献均通过DYRK4抗体验证了其在疾病模型或分子机制中的功能，涵盖神经发育、癌症和纤毛相关疾病领域。如需具体文献链接或补充更多研究，可进一步说明。
The DYRK4 antibody is a research tool designed to detect and study dual-specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4), a member of the DYRK kinase family. DYRK kinases are involved in critical cellular processes, including cell cycle regulation, transcriptional control, and neuronal development. DYRK4. though less characterized than its homologs DYRK1A or DYRK2. has been implicated in spermatogenesis, stress granule dynamics, and cancer progression. It is predominantly expressed in the testis but also detected in other tissues under specific conditions, suggesting context-dependent roles.
Antibodies targeting DYRK4 enable researchers to investigate its expression patterns, subcellular localization, and interactions in physiological and pathological contexts. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies employing DYRK4 antibodies have explored its potential involvement in diseases such as glioblastoma and prostate cancer, where dysregulated DYRK4 expression correlates with tumor aggressiveness or therapy resistance.
The specificity of DYRK4 antibodies is critical due to structural similarities among DYRK family members. Validation often includes knockout cell lines or siRNA-mediated silencing to confirm target selectivity. As DYRK4's functional mechanisms remain incompletely understood, high-quality antibodies are essential for advancing research into its biological significance and therapeutic potential.
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