| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 8798 |
| clone | 1A5C10 |
| WB Predicted band size | 59.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human DYRK4 (AA: 303-515) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于DYRK4抗体的示例参考文献(内容为虚构，仅供参考)：
1. **文献名称**：*"Characterization of DYRK4 Kinase Activity and Its Role in Cell Cycle Progression"*
**作者**：J. Smith et al.
**摘要**：本研究通过开发特异性DYRK4抗体，验证了DYRK4在细胞周期G2/M期调控中的作用。Western blot和免疫荧光实验表明，DYRK4通过磷酸化特定底物参与有丝分裂调控。
2. **文献名称**：*"A Novel Monoclonal Antibody Against DYRK4 for Immunohistochemical Analysis in Human Tissues"*
**作者**：L. Zhang et al.
**摘要**：报道了一种高特异性DYRK4单克隆抗体的制备与验证，并应用于多种癌症组织的免疫组化分析，发现DYRK4在肺癌中表达显著上调，提示其潜在临床意义。
3. **文献名称**：*"DYRK4 Expression and Localization in Neurodegenerative Disease Models"*
**作者**：M. Tanaka et al.
**摘要**：利用商业化DYRK4抗体，通过免疫印迹和免疫组化技术，揭示了DYRK4在阿尔茨海默病模型小鼠脑组织中的异常聚集，提示其与tau蛋白病理相关。
4. **文献名称**：*"Functional Screening of DYRK Family Kinases Using Targeted Antibodies"*
**作者**：R. Kumar et al.
**摘要**：系统评估了DYRK家族成员(包括DYRK4)的抗体特异性，结合CRISPR敲除技术验证抗体可靠性，并发现DYRK4在精子发生过程中高表达。
**建议**：实际文献请通过PubMed、Google Scholar或Web of Science检索，关键词“DYRK4 antibody”或“DYRK4 immunoblotting”。注意筛选近年研究以提高参考价值。
The DYRK4 (Dual Specificity Tyrosine Phosphorylation-Regulated Kinase 4) antibody is a tool used to study the function and expression of the DYRK4 protein, a member of the CMGC kinase group. DYRK4 belongs to the DYRK family, which regulates diverse cellular processes, including cell cycle progression, differentiation, and survival. Unlike its well-characterized relatives DYRK1A or DYRK2. DYRK4 remains less studied, though it shares conserved kinase domains and autophosphorylation activity. It is expressed in tissues like the testis, brain, kidney, and heart, suggesting roles in development and tissue homeostasis.
DYRK4-specific antibodies are essential for detecting protein localization, expression levels, and interactions in experimental models. They enable techniques such as Western blotting, immunoprecipitation, and immunohistochemistry. Research using these antibodies has linked DYRK4 to pathways involving Wnt signaling, RNA processing, and stress responses. Emerging studies implicate DYRK4 dysregulation in diseases; for example, its overexpression has been observed in certain cancers, potentially influencing tumor progression. Additionally, DYRK4 may interact with proteins associated with neurodegenerative conditions, though mechanistic insights are limited.
The development of high-specificity, validated DYRK4 antibodies is critical for clarifying its biological roles and therapeutic potential. Current challenges include minimizing cross-reactivity with other DYRK family members and standardizing detection across experimental platforms. Ongoing research aims to explore DYRK4's involvement in developmental disorders, cancer, and neurological diseases, positioning it as a target for future drug discovery.
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