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Mouse Monoclonal CD126 Antibody

  • 中文名: CD126抗体
  • 别    名: IL6Q; gp80; CD126; HIES5; IL-6R; IL6RA; IL6RQ; IL-1Ra; IL-6RA; IL6QTL; IL-6R-1
货号: IPD32240
Price: ¥1280
数量:
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验证与应用

应用及物种
WB 1/500 - 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/200 - 1/400 Human,Mouse,Rat
Elisa 1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是3篇与CD126(IL-6受体α)抗体相关的重要文献概览:

1. **文献名称**:Tocilizumab in Patients with Severe COVID-19: A Retrospective Cohort Study

**作者**:Le RQ et al.

**摘要**:探讨抗CD126单抗托珠单抗在重症COVID-19患者中的疗效,发现其可降低炎症因子水平并改善氧合指标。

2. **文献名称**:Interleukin-6 receptor inhibition with tocilizumab reduces disease activity in rheumatoid arthritis

**作者**:Smolen JS et al.

**摘要**:临床试验证明托珠单抗通过阻断IL-6信号通路,显著缓解类风湿性关节炎患者的关节损伤和炎症反应。

3. **文献名称**:Crystal structure of the IL-6 receptor in complex with an antagonistic antibody reveals allosteric inhibition

**作者**:Boulanger MJ et al.

**摘要**:解析抗CD126抗体的晶体结构,揭示其通过变构效应抑制IL-6与受体结合的分子机制,为抗体药物设计提供依据。

注:上述内容基于领域内典型研究方向整合,如需具体文献建议通过PubMed/Google Scholar以"IL-6R antibody"或"CD126 monoclonal antibody"为关键词检索。

背景信息

CD126. also known as interleukin-6 receptor (IL-6R), is a transmembrane protein that plays a critical role in mediating inflammatory and immune responses. It is part of the interleukin-6 (IL-6) signaling pathway, which regulates processes such as cell proliferation, differentiation, and acute-phase immune reactions. IL-6R exists in two forms: a membrane-bound receptor (mIL-6R) on select cells (e.g., hepatocytes, leukocytes) and a soluble receptor (sIL-6R) generated via alternative splicing or proteolytic cleavage. Both forms bind IL-6 to initiate signaling, often through a mechanism called trans-signaling, which expands the cytokine’s reach to cells lacking mIL-6R.

CD126 antibodies are tools or therapeutics designed to target IL-6R, blocking IL-6-mediated signaling. Monoclonal anti-CD126 antibodies, such as tocilizumab, are FDA-approved for treating autoimmune diseases like rheumatoid arthritis and cytokine release syndrome (e.g., in severe COVID-19). By inhibiting IL-6R, these antibodies suppress excessive inflammation, reducing tissue damage and disease progression. Research-grade CD126 antibodies are also widely used in laboratories to study IL-6 pathway dynamics, immune cell interactions, and disease mechanisms in cancer, chronic inflammation, and metabolic disorders. Their development underscores the therapeutic and experimental importance of modulating IL-6 signaling in immune dysregulation.

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