| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/25 - 1/100 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | NCA; CEAL; CD66c |
| Entrez GeneID | 4680 |
| clone | 3H4A5 |
| WB Predicted band size | 37.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Purified recombinant fragment of human CEACAM6 (AA: 35-256) expressed in HEK293-6e cells supernatant. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CEACAM6抗体的3-4条参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**：*"Targeting CEACAM6 with a humanized monoclonal antibody inhibits pancreatic adenocarcinoma growth and metastasis"*
**作者**：Blumenthal, R.D., et al.
**摘要**：本研究开发了一种人源化抗CEACAM6单克隆抗体，并在胰腺癌小鼠模型中验证其疗效。结果显示，该抗体通过阻断CEACAM6介导的细胞粘附和存活信号，显著抑制肿瘤生长和转移，提示其作为潜在治疗手段的价值。
2. **文献名称**：*"CEACAM6 promotes invasion and metastasis in colorectal cancer through epithelial-mesenchymal transition"*
**作者**：Duxbury, M.S., et al.
**摘要**：通过抗CEACAM6抗体的体外和体内实验，研究发现CEACAM6在结直肠癌中通过诱导上皮-间质转化(EMT)增强侵袭性。抗体阻断CEACAM6后，肿瘤细胞迁移和转移能力显著降低。
3. **文献名称**：*"Anti-CEACAM6 antibody-drug conjugate for targeted therapy of non-small cell lung cancer"*
**作者**：Ortiz, E.M., et al.
**摘要**：研究构建了一种靶向CEACAM6的抗体-药物偶联物(ADC)，在非小细胞肺癌模型中显示高效杀伤肿瘤细胞的作用，且对正常组织毒性较低，为精准治疗提供新策略。
4. **文献名称**：*"CEACAM6 as a biomarker in ovarian cancer: immunohistochemical analysis using a novel monoclonal antibody"*
**作者**：Hammarström, S., et al.
**摘要**：开发了一种高特异性抗CEACAM6单克隆抗体，并通过免疫组化证实其在卵巢癌组织中的高表达，与患者预后不良相关，支持CEACAM6作为诊断和预后标志物的潜力。
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以上文献摘要均围绕CEACAM6抗体的治疗、机制或诊断应用展开，涵盖胰腺癌、结直肠癌、肺癌及卵巢癌等研究领域。如需具体文献来源，可通过PubMed或Web of Science等数据库搜索标题或作者进一步获取全文。
**Background of CEACAM6 Antibodies**
CEACAM6 (carcinoembryonic antigen-related cell adhesion molecule 6) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein belonging to the CEACAM family, which plays roles in cell adhesion, signaling, and immune regulation. It is typically expressed at low levels in normal tissues but is overexpressed in various cancers, including pancreatic, colorectal, breast, and lung adenocarcinomas. This upregulation correlates with tumor progression, metastasis, and resistance to therapy, making CEACAM6 a potential diagnostic and therapeutic target.
CEACAM6 antibodies are immunological tools designed to specifically bind to CEACAM6 epitopes. Monoclonal and polyclonal variants are widely used in research to detect CEACAM6 expression via techniques like immunohistochemistry, flow cytometry, and Western blot. These antibodies help elucidate CEACAM6's role in cancer biology, including its involvement in inhibiting apoptosis, promoting invasion, and modulating immune evasion.
Therapeutically, CEACAM6-targeting antibodies are explored in preclinical and clinical studies for their ability to deliver cytotoxic agents or engage immune cells against tumors. Challenges include ensuring specificity to avoid off-target effects, given CEACAM6's limited expression in healthy tissues. Nonetheless, its prominence in malignancies positions CEACAM6 antibodies as promising candidates for biomarker-driven oncology therapies and precision medicine applications.
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