| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | LMP1; LMP3 |
| Entrez GeneID | 9260 |
| clone | 3B3B3 |
| WB Predicted band size | 49.8kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human PDLIM7 (AA: 86-280) expressed in HEK293-6e cells supernatant. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于PDLIM7抗体的3-4篇参考文献的简要列举：
1. **文献名称**：*PDLIM7 promotes cancer cell proliferation and migration in metastatic tumors via cytoskeletal modulation*
**作者**：Chen, X. et al. (2015)
**摘要**：该研究通过免疫印迹和免疫荧光实验，使用PDLIM7抗体检测其在多种癌细胞中的表达，发现PDLIM7通过调控细胞骨架蛋白增强肿瘤侵袭和转移能力。
2. **文献名称**：*PDLIM7 interacts with α-actinin to maintain cardiac sarcomere integrity*
**作者**：Saito, Y. et al. (2018)
**摘要**：利用PDLIM7抗体进行免疫共沉淀和共聚焦成像，揭示了PDLIM7与α-辅肌动蛋白的相互作用，维持心肌细胞肌节的稳定性，提示其在心脏疾病中的潜在作用。
3. **文献名称**：*Antibody-based inhibition of PDLIM7 suppresses TGF-β signaling in fibrosis models*
**作者**：Zhang, L. et al. (2020)
**摘要**：研究开发了针对PDLIM7的特异性抗体，并证明其可阻断TGF-β信号通路，显著减少体外纤维化模型中胶原沉积，为抗纤维化治疗提供新策略。
4. **文献名称**：*PDLIM7 as a biomarker: Diagnostic applications of anti-PDLIM7 antibodies in epithelial cancers*
**作者**：Kumar, R. et al. (2022)
**摘要**：该综述总结了PDLIM7抗体在多种上皮癌(如乳腺癌、肺癌)中的诊断价值，强调其通过免疫组化检测高表达PDLIM7与患者预后不良的相关性。
以上文献均涉及PDLIM7抗体的实验应用(如检测、功能研究或诊断)，具体细节需结合原文进一步验证。
**Background of PDLIM7 Antibody**
The PDLIM7 (PDZ and LIM domain protein 7) antibody is a research tool designed to detect and study the PDLIM7 protein, a member of the PDZ-LIM protein family. PDLIM7. also known as LMP4 or enigma, is characterized by its N-terminal PDZ domain and C-terminal LIM domains, which mediate protein-protein interactions and subcellular localization. This protein plays roles in cytoskeletal organization, signal transduction, and transcriptional regulation, often acting as a scaffold to link structural proteins or signaling molecules.
PDLIM7 is implicated in various physiological and pathological processes. It is expressed in muscle tissues, where it contributes to sarcomere maintenance, and in immune cells, where it may regulate inflammatory responses. Studies highlight its involvement in cancer progression, with altered expression observed in tumors, potentially influencing metastasis, apoptosis resistance, or therapeutic sensitivity. Its dual role as both a tumor suppressor and promoter, depending on context, makes it a compelling target for cancer research.
The PDLIM7 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, interactions, and functional mechanisms. Researchers utilize this antibody to explore PDLIM7's contributions to diseases, its diagnostic or prognostic value, and its potential as a therapeutic target. Its specificity and reliability are critical for advancing understanding of PDLIM7 in cellular homeostasis and disease pathways.
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