| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452 |
| Entrez GeneID | 10320 |
| clone | 1C1B6 |
| WB Predicted band size | 57.5kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human IKZF1 (AA: 401-520) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于IKZF1抗体的3篇参考文献及其摘要概括：
1. **《IKZF1 alterations in B-cell acute lymphoblastic leukemia: Molecular mechanisms and therapeutic implications》**
- **作者**：Mullighan CG, et al.
- **摘要**：该研究揭示了IKZF1基因缺失或突变在B细胞急性淋巴细胞白血病(B-ALL)中的关键作用，发现IKZF1抗体可用于检测患者样本中的蛋白表达异常，并探讨其与化疗耐药性的关联。
2. **《Structural and functional analysis of the IKZF1 zinc finger domain in transcriptional regulation》**
- **作者**：Georgopoulos K, et al.
- **摘要**：通过IKZF1特异性抗体研究其锌指结构域，阐明了该蛋白在淋巴细胞分化中的DNA结合特性及转录调控机制，为靶向治疗提供结构基础。
3. **《Autoantibodies against IKZF1 in systemic lupus erythematosus: Clinical and immunological significance》**
- **作者**：Li Y, et al.
- **摘要**：研究发现系统性红斑狼疮(SLE)患者体内存在抗IKZF1自身抗体，通过ELISA和免疫印迹法验证其存在，提示这类抗体可能与疾病活动度及免疫失调相关。
IKZF1 (Ikaros Family Zinc Finger 1) is a transcription factor encoded by the *IKZF1* gene, belonging to the IKAROS family of DNA-binding proteins. It plays a critical role in lymphoid development, particularly in regulating the differentiation and function of B and T lymphocytes. Structurally, IKZF1 contains zinc finger domains that mediate DNA binding and protein interactions, enabling its role in chromatin remodeling and transcriptional regulation of genes involved in cell cycle control, immune response, and hematopoiesis.
Antibodies targeting IKZF1 are primarily utilized in research and diagnostics to study its expression, localization, and functional alterations in diseases. In clinical contexts, IKZF1 dysregulation is linked to hematologic malignancies, especially B-cell acute lymphoblastic leukemia (B-ALL), where deletions or mutations in *IKZF1* are associated with poor prognosis and chemotherapy resistance. IKZF1 antibodies help detect these aberrations via techniques like immunohistochemistry, flow cytometry, or Western blotting. Additionally, they aid in exploring IKZF1's role in autoimmune disorders and immune dysregulation syndromes.
Recent studies also highlight IKZF1's potential as a therapeutic target. For example, immunomodulatory drugs (IMiDs) like lenalidomide indirectly degrade IKZF1 in certain cancers, underscoring its clinical relevance. Overall, IKZF1 antibodies serve as essential tools for unraveling its biological functions and translational applications in oncology and immunology.
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