Mouse Monoclonal KRT10 Antibody

The keratin 10 (KRT10) antibody is a tool used to detect KRT10. a type I acidic keratin protein encoded by the *KRT10* gene. KRT10 is predominantly expressed in the suprabasal layers of stratified epithelial tissues, particularly the epidermis, where it pairs with keratin 1 (KRT1) to form intermediate filaments. These filaments maintain structural integrity and mechanical resilience in differentiating keratinocytes. Mutations in *KRT10* are linked to genetic skin disorders like epidermolytic ichthyosis, characterized by epidermal fragility and hyperkeratosis. In research, KRT10 antibodies are employed to study epidermal differentiation, skin barrier function, and pathological conditions such as psoriasis, skin cancer, or wound healing. They are widely used in techniques like immunohistochemistry, immunofluorescence, and Western blotting to visualize KRT10 distribution and expression levels. Additionally, KRT10 downregulation is observed in certain cancers, including squamous cell carcinomas, suggesting its role as a differentiation marker. The antibody’s specificity helps distinguish between proliferative basal cells (KRT10-negative) and terminally differentiated keratinocytes (KRT10-positive), aiding in diagnostic and mechanistic studies of epithelial diseases. Its applications extend to evaluating therapeutic interventions targeting epidermal homeostasis or genetic skin disorders.