Mouse Monoclonal COL1A2 Antibody

The COL1A2 antibody targets the alpha-2 chain of type I collagen, a critical structural protein encoded by the COL1A2 gene. Type I collagen, the most abundant collagen in vertebrates, forms heterotrimers with two alpha-1 chains (COL1A1) and one alpha-2 chain, providing tensile strength to connective tissues like skin, bone, tendons, and blood vessels. COL1A2 antibodies are widely used in research to study collagen biosynthesis, tissue remodeling, and pathologies linked to type I collagen dysregulation, including fibrosis, osteogenesis imperfecta, and Ehlers-Danlos syndrome. These antibodies enable detection of COL1A2 expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping to map its distribution in healthy versus diseased tissues. In clinical contexts, COL1A2 autoantibodies have been implicated in certain autoimmune disorders, such as systemic sclerosis, where aberrant collagen production drives tissue scarring. Additionally, mutations in COL1A2 are associated with altered collagen structure, leading to brittle bone disorders. Research tools like COL1A2 antibodies also aid in exploring therapeutic strategies targeting collagen metabolism, such as antifibrotic agents or gene therapies. Their specificity and utility make COL1A2 antibodies essential for understanding extracellular matrix biology and developing diagnostics or treatments for collagen-related diseases.