| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | VPREB1; IGI; IGVPB; VPREB |
| Entrez GeneID | 7441 |
| clone | 5F8F3 |
| WB Predicted band size | 16.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD179A (AA: extra 20-145) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3条与CD179A(Igα，编码基因为IGLL1)抗体相关的参考文献概览：
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1. **文献名称**: *The pre-B cell receptor and its role in proliferation and Ig heavy chain allelic exclusion*
**作者**: Melchers, F.
**摘要**: 该研究阐明了pre-B细胞受体(pre-BCR)在B细胞发育早期的作用，指出CD179A(Igα)与λ5蛋白(CD179B)共同组成pre-BCR复合物，调控B细胞前体的增殖与Ig重链等位基因排斥现象。
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2. **文献名称**: *Aberrant rearrangement of the Ig heavy chain gene in CD179A-deficient mice*
**作者**: Kudo, A., et al.
**摘要**: 通过基因敲除小鼠模型，研究发现CD179A缺失导致Ig重链(IgH)基因重排异常，证实CD179A在B细胞受体信号传导及早期B细胞成熟中的关键作用。
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3. **文献名称**: *Mutations in CD179A disrupt B cell development and cause immunodeficiency*
**作者**: Minegishi, Y., et al.
**摘要**: 该文献报道了人类CD179A基因突变病例，突变导致pre-BCR功能缺陷，引发严重B细胞发育阻滞和抗体缺乏症，强调了CD179A在人类免疫系统中的必要性。
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以上研究均聚焦于CD179A在B细胞发育、抗体生成及免疫疾病中的分子机制。如需具体文献信息，建议通过PubMed或专业数据库检索标题或作者进一步获取全文。
The CD179a antibody targets CD179a, also known as immunoglobulin alpha (Igα) or CD79a, a key component of the B-cell receptor (BCR) complex. CD179a pairs with CD179b (Igβ or CD79b) to form a heterodimer essential for BCR assembly, surface expression, and signal transduction. Structurally, CD179a contains an extracellular immunoglobulin (Ig)-like domain, a transmembrane region, and a cytoplasmic tail with immunoreceptor tyrosine-based activation motifs (ITAMs). These ITAMs recruit signaling molecules like Syk kinase upon BCR engagement, initiating downstream pathways critical for B-cell development, activation, and antigen response.
CD179a is expressed exclusively during B-cell lineage development, from pro-B to mature B cells, making it a specific marker for B-cell identification. Dysregulation of CD179a-mediated signaling is linked to B-cell malignancies (e.g., leukemia, lymphoma) and autoimmune disorders. Antibodies against CD179a are widely used in research to study BCR dynamics, B-cell maturation defects, and disease mechanisms. In diagnostics, CD179a antibodies help classify B-cell neoplasms via flow cytometry or immunohistochemistry. Therapeutically, they are explored for targeting BCR-positive cancers or modulating aberrant immune responses. However, their clinical application remains experimental, with challenges including specificity and off-target effects. Overall, CD179a antibodies serve as vital tools for unraveling B-cell biology and developing precision therapies.
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