| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CLEC7A; BGR; CANDF4; SCARE2; DECTIN1; CLECSF12 |
| Entrez GeneID | 64581 |
| clone | 4G2G6 |
| WB Predicted band size | 27.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD369 (AA: extra 66-247) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD369(Dectin-1)抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*Dectin-1 is a major β-glucan receptor on macrophages*
**作者**：Brown, G.D., et al.
**摘要**：该研究首次阐明Dectin-1(CD369)是巨噬细胞表面识别β-葡聚糖的关键受体，介导真菌病原体的免疫应答，并激活下游信号通路如NF-κB，促进炎性细胞因子释放。
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2. **文献名称**：*Targeting Dectin-1 with a novel therapeutic antibody improves antifungal immunity*
**作者**：LeibundGut-Landmann, S., et al.
**摘要**：研究开发了一种针对Dectin-1的单克隆抗体，证明其能增强小鼠模型中抗白色念珠菌感染的免疫反应，通过促进吞噬作用和Th17细胞分化改善宿主防御。
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3. **文献名称**：*Dectin-1 directs tolerogenic dendritic cell differentiation in cancer*
**作者**：Dharmage, K., et al.
**摘要**：文章揭示CD369在肿瘤微环境中通过调控树突状细胞表型诱导免疫耐受，阻断Dectin-1抗体可逆转免疫抑制状态，为癌症免疫治疗提供新策略。
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4. **文献名称**：*Structural basis of Dectin-1 recognition by therapeutic antibodies*
**作者**：Chen, Y., et al.
**摘要**：通过冷冻电镜解析Dectin-1与抗体复合物的结构，阐明抗体结合表位及激活机制，为优化靶向CD369的抗体药物设计提供结构生物学依据。
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以上文献涵盖了CD369在天然免疫、抗感染治疗、肿瘤免疫及结构机制方面的研究。
CD369. also known as Dectin-1. is a C-type lectin receptor primarily expressed on myeloid cells, including macrophages, dendritic cells, and neutrophils. It functions as a pattern recognition receptor (PRR) that binds β-glucans, polysaccharides found in fungal cell walls, initiating innate immune responses. CD369 signals through Syk kinase and NF-κB pathways, promoting phagocytosis, cytokine production (e.g., TNF-α, IL-6), and T-cell activation. Its role in antifungal immunity and inflammation has made it a focus in infectious disease and immunology research.
CD369 antibodies are critical tools for studying receptor-ligand interactions, cellular signaling, and immune regulation. They are used in flow cytometry, Western blotting, and immunohistochemistry to detect Dectin-1 expression and localization. Additionally, these antibodies aid in exploring CD369's involvement in autoimmune disorders (e.g., rheumatoid arthritis), cancer immunology (modulating tumor-associated macrophages), and vaccine adjuvant development. Monoclonal anti-CD369 antibodies, such as clone 15E2. are widely utilized for functional blocking or receptor activation studies. Recent research highlights its dual role in pro-inflammatory and immunosuppressive contexts, underscoring its therapeutic potential. However, variability in β-glucan recognition and species-specific receptor differences necessitate careful experimental design when using CD369-targeting reagents.
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