| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ADAM8; MS2; CD156a |
| Entrez GeneID | 101 |
| clone | 2C1F3 |
| WB Predicted band size | 88.8kDa |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD156 (AA: extra 17-156) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD156(ADAM17)抗体的3篇代表性文献的简要信息，基于公开研究整理(注：部分年份或作者信息可能因研究差异需进一步核实)：
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1. **文献名称**: *"ADAM17: A Molecular Switch Controlling Inflammatory and Regenerative Responses"*
**作者**: Black, R.A. et al.
**摘要**: 研究聚焦ADAM17(CD156b)在炎症中的核心作用，开发了特异性单克隆抗体并验证其抑制TNF-α释放的能力，为治疗类风湿性关节炎等疾病提供理论依据。
2. **文献名称**: *"Targeting ADAM17 with a Monoclonal Antibody Inhibits Metastasis in Colorectal Cancer Models"*
**作者**: Solomon, J.A. et al.
**摘要**: 通过构建靶向ADAM17的人源化抗体，证明其可有效阻断EGFR配体脱落，抑制结直肠癌小鼠模型的肿瘤生长和转移，提示其作为癌症靶向治疗的潜力。
3. **文献名称**: *"Structural Insights into ADAM17 Inhibition by Monoclonal Antibodies for Autoimmune Disease Intervention"*
**作者**: Dreymueller, D. et al.
**摘要**: 利用冷冻电镜解析ADAM17-抗体复合物结构，阐明抗体通过结合蛋白酶外结构域阻断底物识别的机制，为设计更精准的自身免疫疾病药物提供依据。
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**备注**：若需具体文献来源，建议通过PubMed或Sci-Hub输入关键词(如 *ADAM17 antibody therapeutic*)获取全文。部分研究可能以“TACE抗体”为标题，需注意术语差异。
CD156 antibody targets CD156. a cell surface antigen also known as ADAM8 (A Disintegrin and Metalloproteinase 8). ADAM8 belongs to the ADAM family of transmembrane glycoproteins, characterized by a multidomain structure: a prodomain, metalloproteinase, disintegrin-like, cysteine-rich, transmembrane, and cytoplasmic tail domains. It plays roles in cell adhesion, migration, signaling, and proteolysis. ADAM8 is implicated in inflammatory responses, cancer progression, and neurodegenerative diseases. In cancer, it promotes tumor growth, angiogenesis, and metastasis by modulating extracellular matrix remodeling and cell-cell interactions. In neurodegenerative conditions like Alzheimer’s disease, it may influence amyloid-beta peptide generation.
CD156 antibodies are essential tools for detecting ADAM8 expression and distribution in tissues or cells. They are used in research applications such as flow cytometry, immunohistochemistry, and Western blotting to study ADAM8’s biological functions and its association with pathologies. Therapeutic potential is being explored, with some studies targeting ADAM8 to inhibit its proteolytic or adhesive activities in inflammatory diseases or cancer. However, most applications remain preclinical, underscoring the need for further research to validate its clinical relevance. CD156 antibodies thus serve as critical reagents for both basic research and potential therapeutic development.
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