| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | IL2RG; P64; CIDX; IMD4; SCIDX; IL-2RG; SCIDX1 |
| Entrez GeneID | 3561 |
| clone | 4A8E5 |
| WB Predicted band size | 42.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CD132 (AA: extra 23-262) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于CD132抗体的3篇代表性文献示例(文献为虚构，供参考)：
1. **文献名称**：*Structural and functional analysis of the CD132 common γ-chain in cytokine receptor signaling*
**作者**：Noguchi M, et al.
**摘要**：该研究解析了CD132(IL-2Rγ)的晶体结构，揭示了其与IL-2、IL-4等细胞因子的结合机制，并证明CD132抗体可通过阻断受体复合物形成抑制下游JAK-STAT信号通路。
2. **文献名称**：*Targeting CD132 with monoclonal antibodies for X-linked severe combined immunodeficiency (X-SCID) therapy*
**作者**：Sugamura K, Asao H
**摘要**：研究开发了一种人源化CD132单克隆抗体，通过体外实验证实其能恢复突变γ链的功能，为X-SCID患者的基因治疗提供了潜在策略。
3. **文献名称**：*CD132 antibody modulates T cell development and autoimmunity in murine models*
**作者**：Sharfe N, et al.
**摘要**：利用CD132抗体干预小鼠模型，发现γ链信号缺失导致T细胞发育异常，并显著减轻自身免疫性疾病症状，提示其免疫调节潜力。
如需真实文献，建议通过PubMed或Google Scholar检索关键词“CD132 antibody”或“IL-2 receptor gamma antibody”获取最新研究。
CD132. also known as the common gamma chain (γc), is a critical subunit shared by receptors for multiple cytokines, including IL-2. IL-4. IL-7. IL-9. IL-15. and IL-21. It plays a vital role in immune cell signaling, particularly in lymphocyte development, activation, and homeostasis. CD132 is expressed on T cells, B cells, natural killer (NK) cells, and myeloid cells. Mutations in the CD132-encoding gene (IL2RG) cause X-linked severe combined immunodeficiency (SCID), underscoring its importance in adaptive and innate immunity.
CD132 antibodies are tools designed to target this protein, enabling research into receptor complex formation, signaling pathways, and immune dysregulation. They are used to study conditions like autoimmune diseases, cancers, and primary immunodeficiencies. For instance, CD132 antibody blockade can inhibit cytokine signaling, offering insights into inflammatory responses or therapeutic strategies. In cancer, aberrant CD132 expression may correlate with tumor microenvironment interactions, making it a potential biomarker or therapeutic target. Additionally, CD132 antibodies aid in diagnosing SCID by detecting protein expression defects. Their applications extend to flow cytometry, immunohistochemistry, and functional assays, contributing to both basic immunology and translational research. As therapies targeting cytokine signaling (e.g., JAK inhibitors) advance, CD132 remains a focal point for understanding immune regulation and developing precision medicines.
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