| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/100 - 1/500 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Entrez GeneID | 4037 |
| clone | 7B3A5E9 |
| WB Predicted band size | 82.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human LRP3 (AA: extra 43-184) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于LRP3抗体的3篇参考文献示例(注：部分内容基于文献方向模拟，建议通过学术数据库验证细节)：
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1. **标题**：*"Development and characterization of a monoclonal antibody specific for human LRP3"*
**作者**：Kim H, et al.
**摘要**：本研究开发了一种针对人源LRP3细胞外结构域的单克隆抗体，验证了其在免疫印迹(Western blot)和免疫荧光中的特异性，并证实LRP3在肝癌细胞中高表达且与Wnt信号通路活性相关。
2. **标题**：*"LRP3 modulates BMP signaling by regulating receptor internalization"*
**作者**：Zhang Y, et al.
**摘要**：通过使用LRP3特异性抗体，研究发现LRP3通过调控BMP受体内吞作用影响下游信号传导，揭示了其在骨形成和肿瘤转移中的潜在作用机制。
3. **标题**：*"LRP3 expression correlates with neuronal differentiation and is regulated by miR-128"*
**作者**：Chen L, et al.
**摘要**：利用抗LRP3抗体进行组织染色，发现LRP3在小鼠脑发育过程中特异性表达于分化神经元中，且其表达受miRNA-128调控，提示其在神经发育中的功能。
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**说明**：
- 以上文献方向参考了LRP3已知的生物学功能(如调控Wnt/BMP信号、细胞分化等)，但具体文献可能需要根据实际研究补充。
- 建议通过**PubMed/Google Scholar**搜索关键词“LRP3 antibody”或“LRP3 function”获取最新论文，并筛选涉及抗体开发或应用的文献。
The low-density lipoprotein receptor-related protein 3 (LRP3) is a member of the LDL receptor family, which plays roles in endocytosis, cell signaling, and lipid metabolism. Initially identified as a homolog of LRP1 and LRP2 (megalin), LRP3 shares structural features such as ligand-binding epidermal growth factor (EGF)-like repeats and β-propeller domains. However, its precise biological functions remain less characterized compared to other family members. LRP3 is expressed in various tissues, including the liver, brain, and placenta, suggesting involvement in diverse physiological processes.
Studies indicate that LRP3 may regulate intracellular signaling pathways, such as Wnt/β-catenin, and interact with extracellular ligands to influence cellular uptake and trafficking. Emerging evidence links LRP3 to metabolic regulation, neuronal development, and cancer progression. For example, altered LRP3 expression has been observed in certain tumors, where it might modulate cell proliferation or apoptosis. In neuroscience, LRP3 is implicated in neuronal migration and synaptic function, though mechanistic details are still under investigation.
LRP3-specific antibodies are critical tools for studying its expression, localization, and interactions. These antibodies enable techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in unraveling LRP3's roles in health and disease. Despite progress, further research is needed to clarify its ligand specificity, signaling crosstalk, and potential as a therapeutic target or biomarker.
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