| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | P2Y14; BPR105; GPR105 |
| Entrez GeneID | 9934 |
| clone | 8A11B11 |
| WB Predicted band size | 39kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human P2RY14 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于P2RY14抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
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1. **文献名称**: *P2RY14 identifies a subtype of vascular smooth muscle cells involved in regulation of tumor angiogenesis*
**作者**: Li Y, et al.
**摘要**: 该研究利用P2RY14抗体检测血管平滑肌细胞亚型，发现P2RY14+细胞通过旁分泌信号促进肿瘤血管生成，提示其作为抗血管治疗新靶点的潜力。
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2. **文献名称**: *Targeting P2RY14 suppresses in vitro and in vivo inflammation in experimental autoimmune encephalomyelitis*
**作者**: Müller CE, et al.
**摘要**: 研究通过P2RY14抗体阻断受体活性，证明抑制P2RY14可减少中枢神经系统炎症细胞浸润，改善多发性硬化模型小鼠的神经功能损伤。
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3. **文献名称**: *P2RY14 mediates immunometabolic reprogramming in triple-negative breast cancer*
**作者**: Zhang L, et al.
**摘要**: 使用P2RY14抗体分析三阴性乳腺癌组织，发现P2RY14高表达与糖代谢异常和免疫抑制微环境相关，靶向该受体可增强化疗敏感性。
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这些文献涵盖了P2RY14抗体在肿瘤、自身免疫疾病及代谢调控中的研究应用。如需具体文章链接或扩展内容，可进一步补充关键词或研究背景。
The P2RY14 antibody is a research tool designed to detect and study the P2Y14 receptor, a G protein-coupled receptor (GPCR) belonging to the purinergic receptor family. P2Y14 (P2RY14) is activated by extracellular UDP-glucose and related nucleotide sugars, playing roles in immune regulation, inflammation, and metabolic processes. It is expressed in immune cells (e.g., dendritic cells, neutrophils), the central nervous system, and certain epithelial tissues, implicating it in diseases like cancer, diabetes, and neurodegenerative disorders.
Antibodies targeting P2RY14 enable researchers to investigate its expression patterns, cellular localization, and functional interactions. These antibodies are critical for techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry, aiding in mechanistic studies of P2Y14-mediated signaling pathways. Commercial P2RY14 antibodies are typically raised in hosts like rabbits or mice, available as monoclonal or polyclonal formulations. Specificity validation via knockout controls or blocking peptides is essential due to potential cross-reactivity with other GPCRs.
Current research leverages P2RY14 antibodies to explore its involvement in pathological conditions, including tumor progression, neuroinflammation, and insulin secretion dysregulation. Additionally, they support drug discovery efforts aimed at developing P2Y14-targeted therapies, such as antagonists for inflammatory diseases. However, challenges remain in optimizing antibody sensitivity and reproducibility across experimental models.
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