| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 1/200 - 1/1000 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | P2Y14; BPR105; GPR105 |
| Entrez GeneID | 9934 |
| clone | 5A3F1 |
| WB Predicted band size | 39kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human P2RY14 (AA: extra mix) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于P2RY14抗体的3篇模拟参考文献示例(注：内容为虚构，仅用于格式参考)：
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1. **文献名称**：*P2RY14 Antibody-Based Detection of Receptor Overexpression in Inflammatory Bowel Disease*
**作者**：Chen L, et al.
**摘要**：本研究开发了一种高特异性P2RY14抗体，用于检测炎症性肠病(IBD)患者肠道组织中P2RY14的表达水平。结果显示，P2RY14在IBD患者的巨噬细胞和上皮细胞中显著上调，提示其可能通过调节嘌呤信号通路参与黏膜炎症反应。
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2. **文献名称**：*Targeting P2RY14 with Neutralizing Antibodies Attenuates Cancer-Associated Fibrosis*
**作者**：Gomez-Ramos A, et al.
**摘要**：通过筛选单克隆抗体库，研究者鉴定出能够阻断P2RY14与尿苷二磷酸葡萄糖(UDP-glucose)结合的抗体。实验表明，该抗体可抑制肿瘤微环境中成纤维细胞的活化，减少胰腺癌模型中的纤维化进展。
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3. **文献名称**：*P2RY14 Antibody Reveals Sex-Specific Expression in Metabolic Syndrome*
**作者**：Kato S, et al.
**摘要**：利用新型P2RY14抗体进行组织染色，发现代谢综合征小鼠的脂肪组织中P2RY14表达存在性别差异。雌性小鼠的受体表达与胰岛素抵抗呈负相关，提示其可能参与性别特异性代谢调控。
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(注：以上文献为示例性内容，实际研究中需引用真实发表文献。)
The P2RY14 antibody is designed to target the P2Y14 receptor, a G protein-coupled receptor (GPCR) belonging to the purinergic receptor family. P2Y14 is activated by extracellular UDP-glucose and related nucleotide sugars, distinguishing it from other P2Y receptors that primarily bind nucleotides like ATP or ADP. This receptor plays a role in modulating immune responses, inflammation, and metabolic processes, with expression observed in immune cells (e.g., mast cells, dendritic cells), the nervous system, and certain epithelial tissues. Research highlights its involvement in diseases such as asthma, diabetes, and cancer, where it may regulate cell migration, cytokine release, or tumor progression.
P2RY14 antibodies are critical tools for detecting receptor expression, localization, and functional studies. They enable applications like Western blotting, immunohistochemistry, and flow cytometry to explore P2Y14's physiological and pathological roles. Challenges include low receptor abundance in tissues and potential cross-reactivity with other proteins, necessitating rigorous validation. Recent studies also investigate P2Y14 as a therapeutic target, driving interest in developing agonists/antagonists. However, its signaling mechanisms and disease-specific contributions remain incompletely understood, underscoring the need for high-quality antibodies to advance research in immunology, oncology, and drug discovery.
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